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[营养支持在肝性脑病患者中的重要性]

[Importance of nutritional support in patients with hepatic encephalopathy].

作者信息

Jurado García J, Costán Rodero G, Calañas-Continente A

机构信息

Servicio de Aparato Digestivo, Hospital Universitario Reina Sofía, Córdoba, España.

出版信息

Nutr Hosp. 2012 Mar-Apr;27(2):372-81. doi: 10.1590/S0212-16112012000200006.

Abstract

Protein calorie malnutrition is frequently a complication in the chronic liver disease patient and is considered to be a negative prognostic factor. Anorexia and several other endocrine metabolic complications produce an hypermetabolic state that needs more caloric intake. Hepatic encephalopathy is one of the developments possible in patients with descompensated cirrhosis. The wellknown role of ammonia in the pathogenesis of hepatic encephalopathy has determined a restriction in dietary protein along many decades. Nevertheless, there is no evidence about a low protein diet being better in the outcome of hepatic encephalopathy, it worsens, moreover, the nutritional status and helps in the development of many nutritional related complications. This article reviews the use of oral branched-chain amino acids and proteins of different sources, probiotics, synbiotics, antioxidants, oral L-Ornithine L-Aspartate and acetyl-L-carnitine in patients with hepatic encephalopathy.

摘要

蛋白质热量营养不良在慢性肝病患者中常常是一种并发症,并且被认为是一个负面的预后因素。厌食和其他一些内分泌代谢并发症会产生一种高代谢状态,这需要更多的热量摄入。肝性脑病是失代偿期肝硬化患者可能出现的情况之一。几十年来,氨在肝性脑病发病机制中的众所周知的作用决定了对饮食蛋白质的限制。然而,没有证据表明低蛋白饮食对肝性脑病的预后更好,此外,它会恶化营养状况并助长许多与营养相关的并发症的发生。本文综述了口服支链氨基酸和不同来源的蛋白质、益生菌、合生元、抗氧化剂、口服L-鸟氨酸L-天冬氨酸和乙酰-L-肉碱在肝性脑病患者中的应用。

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