Ulutatar Çağrı Ünal, Ulutatar Fırat, DuruÖz Mehmet Tuncay
Department of Physical Medicine and Rehabilitation, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul, Turkey.
Department of Physical Medicine and Rehabilitation, Pain Medicine Division, Çukurova University School of Medicine, Adana, Turkey.
Arch Rheumatol. 2019 Dec 17;35(3):409-415. doi: 10.46497/ArchRheumatol.2020.7215. eCollection 2020 Sep.
This study aims to examine the presence of neuropathic pain (NP) in psoriatic arthritis (PsA) and its relationship with functional parameters.
The study included 50 PsA patients (18 males, 32 females; mean age 50 years; range, 27 to 68 years) diagnosed according to The Classification Criteria for Psoriatic Arthritis. NP was assessed with PainDETECT questionnaire (PDQ). Associations of NP with quality of life (QoL), sleep and fatigue were analyzed by filling out the Psoriatic Arthritis Quality of Life (PsAQoL), Pittsburgh Sleep Quality Index (PSQI), and Multidimensional Assessment of Fatigue (MAF) scales, respectively. Group analysis was performed with independent-samples Mann-Whitney U test and Kruskal-Wallis test. Spearman's rank correlation coefficient (rho) was used for correlations between functional parameters.
Mean disease duration of the PsA patients was 90.2±90.8 months]. The number of patients with ambiguous NP was eight (3 males, 5 females) while likely NP was detected in 12 patients (2 males, 10 females). The median scores of visual analog scale-pain, PSQI, PsAQoL and MAF were significantly higher in patients with NP (p<0.05). The correlations between PDQ and other functional parameters were found moderate-strong calculated as follows: PSQI (rho=0.44, p=0.003), MAF (rho=0.42, p=0.005), PsAQoL (rho=0.73, p<0.0001).
The existence of NP in PsA is not rare and it has a significant relationship with impaired QoL and sleep disturbances. The assessment of NP in PsA patients is necessary to provide a holistic treatment strategy.
本研究旨在检测银屑病关节炎（PsA）患者中神经性疼痛（NP）的存在情况及其与功能参数的关系。
本研究纳入了50例根据银屑病关节炎分类标准确诊的PsA患者（18例男性，32例女性；平均年龄50岁；范围为27至68岁）。采用疼痛检测问卷（PDQ）评估NP。分别通过填写银屑病关节炎生活质量（PsAQoL）量表、匹兹堡睡眠质量指数（PSQI）和疲劳多维评估（MAF）量表，分析NP与生活质量（QoL）、睡眠和疲劳的相关性。采用独立样本曼-惠特尼U检验和克鲁斯卡尔-沃利斯检验进行组间分析。使用斯皮尔曼等级相关系数（rho）分析功能参数之间的相关性。
PsA患者的平均病程为90.2±90.8个月。NP情况不明确的患者有8例（3例男性，5例女性），而12例患者（2例男性，10例女性）被检测出可能存在NP。NP患者的视觉模拟评分-疼痛、PSQI、PsAQoL和MAF的中位数得分显著更高（p<0.05）。PDQ与其他功能参数之间的相关性为中度至高度，计算如下：PSQI（rho=0.44，p=0.003），MAF（rho=0.42，p=0.005），PsAQoL（rho=0.73，p<0.0001）。
PsA患者中NP的存在并不罕见，且与生活质量受损和睡眠障碍有显著关系。对PsA患者进行NP评估对于提供全面的治疗策略很有必要。
