Dip. Scienze della Salute, sezione Dermatologia, Universita' degli Studi di Firenze, Firenze, Italy.
St John's Institute of Dermatology, GSTT NHS Foundation Trust, London, UK.
Photodermatol Photoimmunol Photomed. 2021 Jul;37(4):334-342. doi: 10.1111/phpp.12658. Epub 2021 Feb 1.
Phototherapy is a mainstay for the treatment of MF. However, there is scarce evidence for its use, mostly due to the lack of a unified schedule.
The primary aim of this study was to establish the first structured, expert-based consensus regarding the indications and technical schedules of NB-UVB and PUVA for MF. The secondary aim was to determine the consensus level for each specific item.
MATERIALS & METHODS: E-delphi study. Item-specific expert consensus was defined as the number of "Totally Agree" results to ≥80% of the panelists. Cronbach alpha index ≥0.7 was used as a measure of homogeneity in the responses among questions related to the same topic.
Overall, there was a high homogeneity among responders (0.78). On specific topics, the highest grade was observed for technical items (0.8) followed by indications for early (0.73) and advanced stages (0.7).
Items related to the most canonical indications of phototherapy and to treatment schedules showed the highest agreements rates. There is consensus about the use of standardized treatment schedules for the induction and consolidation phases for NB-UVB and PUVA in MF.
光疗是 MF 治疗的主要手段。然而，由于缺乏统一的方案，其应用证据很少。
本研究的主要目的是就 NB-UVB 和 PUVA 治疗 MF 的适应证和技术方案建立第一个基于专家的结构化共识。次要目的是确定每个具体项目的共识水平。
电子德尔菲研究。特定于项目的专家共识定义为对 ≥80%的小组成员表示“完全同意”的结果数量。Cronbach alpha 指数≥0.7 用于衡量与同一主题相关的问题之间的响应一致性。
总体而言，应答者之间具有高度的同质性（0.78）。在具体主题上，技术项目的评分最高（0.8），其次是早期（0.73）和晚期（0.7）的适应证。
与光疗最典型适应证和治疗方案相关的项目显示出最高的一致性。对于 NB-UVB 和 PUVA 在 MF 中的诱导和巩固阶段，有使用标准化治疗方案的共识。
