Castro Sebastián, Velasco Suárez Carlos, Vieites Ana, Bergadá Ignacio, Cassinelli Hamilton
Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Fundación de Endocrinología Infantil (FEI), División de Endocrinología, Hospital de Niños "Ricardo Gutiérrez", Ciudad Autónoma de Buenos Aires.
Hospital Alemán, Consultorios Pediátricos, Ciudad Autónoma de Buenos Aires, Argentina.
Arch Argent Pediatr. 2021 Feb;119(1):e49-e53. doi: 10.5546/aap.2021.e49.
The rickets is a disease that affects the differentiation and mineralization of the growth cartilage, as an ultimate consequence of a balance loss in calcium and phosphate levels. Vitamin D deficiency is the most common cause of the rickets (nutritional rickets). Its clinical manifestation during the first years of life involves long bones epiphysis in a more severe way. We report an 8-month-old infant who was diagnosed with cow´s milk protein allergy and suffered from multiple fractures while receiving elemental formula as part of his treatment. The final etiology was hypophosphatemic rickets secondary to phosphate deficiency, and after 3 months of phosphate, calcium and calcitriol supplementation, in addition to the gradually reduction of the proportion of elemental formula intake and the decline of the antacid doses, clinical and radiological heal was achieved.
佝偻病是一种影响生长软骨分化和矿化的疾病，是钙磷水平平衡失调的最终结果。维生素D缺乏是佝偻病（营养性佝偻病）最常见的病因。其在生命最初几年的临床表现以更严重的方式累及长骨骨骺。我们报告一名8个月大的婴儿，他被诊断为牛奶蛋白过敏，在接受元素配方奶粉作为治疗一部分时发生了多处骨折。最终病因是继发于磷酸盐缺乏的低磷性佝偻病，在补充磷酸盐、钙和骨化三醇3个月后，除了逐渐减少元素配方奶粉摄入量的比例和减少抗酸剂剂量外，实现了临床和影像学治愈。
