系统性红斑狼疮患者隔日皮质类固醇治疗的情绪影响

Mood effects of alternate-day corticosteroid therapy in patients with systemic lupus erythematosus.

作者信息

Joffe R T, Denicoff K D, Rubinow D R, Tsokos G, Balow J E, Pillemer S E

机构信息

Department of Psychiatry, St. Michael's Hospital.

出版信息

Gen Hosp Psychiatry. 1988 Jan;10(1):56-60. doi: 10.1016/0163-8343(88)90085-0.

DOI:10.1016/0163-8343(88)90085-0

PMID:3345908

Abstract

Mood and cognition were assessed on consecutive days in 18 female patients with systemic lupus erythematosus on alternate-day corticosteroid therapy. No overall differences in mood and cognition were observed between the on- and off-medication days. However, 10 patients showed marked worsening or improvement of either depression or anxiety on their off-medication day. Two weeks of prospective behavioral ratings confirmed the observed mood changes in several patients. The clinical and theoretical implications of these findings are discussed.

摘要

对18名接受隔日糖皮质激素治疗的系统性红斑狼疮女性患者连续数天进行了情绪和认知评估。服药日和停药日之间未观察到情绪和认知方面的总体差异。然而，10名患者在停药日出现了抑郁或焦虑的明显加重或改善。两周的前瞻性行为评分证实了部分患者出现了观察到的情绪变化。本文讨论了这些发现的临床和理论意义。