极光 B 和 Haspin 激酶在中期拓扑异构酶 II 检查点中的作用。
Role of Aurora B and Haspin kinases in the metaphase Topoisomerase II checkpoint.
机构信息
Department of Genetics, Cell Biology & Development, University of Minnesota , Minneapolis, MN, USA.
Department of Molecular Biosciences, University of Kansas , Lawrence, KS, USA.
出版信息
Cell Cycle. 2021 Feb;20(4):345-352. doi: 10.1080/15384101.2021.1875671. Epub 2021 Jan 18.
Abstract
DNA Topoisomerase II (TopoII) uses ATP hydrolysis to decatenate chromosomes so that sister chromatids can faithfully segregate in mitosis. When the TopoII enzyme cycle stalls due to failed ATP hydrolysis, the onset of anaphase is delayed, presumably to allow extra time for decatenation to be completed. Recent evidence revealed that, unlike the spindle assembly checkpoint, this TopoII checkpoint response requires Aurora B and Haspin kinases and is triggered by SUMOylation of the C-terminal domain of TopoII.
摘要
DNA 拓扑异构酶 II（TopoII）利用 ATP 水解来解链染色体，以使姐妹染色单体在有丝分裂中忠实地分离。当 TopoII 酶循环因 ATP 水解失败而停滞时，后期的开始会被延迟，大概是为了给解链完成留出更多的时间。最近的证据表明，与纺锤体装配检查点不同，这种 TopoII 检查点反应需要 Aurora B 和 Haspin 激酶，并由 TopoII C 末端结构域的 SUMO 化触发。
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