Zinchuk M S, Avedisova A S, Voinova N I, Kustov G V, Pashnin E V, Gulyaeva N V, Guekht A B
Scientific and Practical Psychoneurological Center, Moscow, Russia.
Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(12):144-152. doi: 10.17116/jnevro2020120121144.
This review focuses on studies of pain threshold and tolerance in individuals with nonsuicidal self-injurious (NSSI) behavior. The data on methods of pain sensitivity studies are presented, with issues in animal modeling of NSSI discussed separately. The results of neuroimaging studies on pain sensitivity in individuals with NSSI are described, along with contribution of genetic factors, psychological variables, and disturbances in opioid and hypothalamic-pituitary-adrenal systems. A critical methodological analysis of the studies on pain sensitivity in individuals with NSSI was performed.
本综述聚焦于对有非自杀性自伤（NSSI）行为个体的疼痛阈值和耐受性的研究。文中呈现了疼痛敏感性研究方法的数据，并单独讨论了NSSI动物模型中的问题。描述了关于NSSI个体疼痛敏感性的神经影像学研究结果，以及遗传因素、心理变量、阿片类物质和下丘脑 - 垂体 - 肾上腺系统紊乱的作用。对NSSI个体疼痛敏感性研究进行了批判性的方法学分析。
