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尿石症诊断。形态和成分分析。

Urinary stone diagnosis. Morphologic and composition analysis.

机构信息

Laboratorio de Investigación en Litiasis Renal. Instituto Universitario de Investigación en Ciencias de la Salud (IUNICSIDISBA). Universidad de las Islas Baleares. Palma de Mallorca. España.

出版信息

Arch Esp Urol. 2021 Jan;74(1):35-48.

Abstract

Analysis of urinary stones is an essential step in establishing the diagnosis and treatment of the stone patient. In fact, the need for an exhaustive study of the stones increases as the relationships between the type of stone and the etiological factors that predispose to this disease become evident. The enumeration (qualitative or quantitative) of the major components that make up the kidney stone (calcium oxalate monohydrate, calcium oxalate dihydrate, uric acid, calcium phosphates, cystine), which is obtained by the most commonly used analytical method, infrared spectroscopy (IR), is no longer enough to guide the urologist on the etiology of the disease. Only a detailed structural analysis and macro and micro components can provide key information on the etiology of the stone, and therefore, on the possible causes that have led to its formation. This study should conclude with a report that is provided to the Urologist. Obtaining this report involves a detailed study, sample by sample, which involves the systematic handling of stereoscopic microscopy, IR spectroscopy and scanning electron microscopy (SEM) with energy dispersive X-raymicroanalysis (EDAX).

摘要

尿石分析是确定结石患者诊断和治疗的重要步骤。事实上,随着结石类型与导致这种疾病的病因因素之间的关系变得明显,对结石进行详尽研究的必要性也随之增加。通过最常用的分析方法——红外光谱(IR)对构成肾结石的主要成分(一水合草酸钙、二水合草酸钙、尿酸、磷酸钙、胱氨酸)进行枚举(定性或定量),这已经不足以指导泌尿科医生了解疾病的病因。只有详细的结构分析和宏观及微观成分才能提供关于结石病因的关键信息,因此也能提供导致结石形成的可能原因的关键信息。这项研究应以提供给泌尿科医生的报告作为结论。要获得这份报告,需要对样本进行详细研究,涉及到立体显微镜、IR 光谱和扫描电子显微镜(SEM)与能量色散 X 射线微分析(EDAX)的系统处理。

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