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结石患者的饮食和生活方式建议。

Dietetic and lifestyle recommendations for stone formers.

机构信息

Fondazione Policlinico Universitario A. Gemelli IRCCS. Roma. Italia. Università Cattolica del Sacro Cuore. Roma. Italia.

出版信息

Arch Esp Urol. 2021 Jan;74(1):112-122.

Abstract

Nutrition is tightly associated with the risk of stone events. A part from genetic predisposition, a correct and balanced diet might prevent incident kidney stones. Several studies analyzed each dietary component and different diets to better understand their impact on stone recurrence. Fluids: High fluids intake is the most important factor for preventing kidney stones disease and for every 200 mL of water, the risk of stones is reduced by 13%. Soft drinks seems to be associated to a greater risk of stone events, whereas caffeine and citrus fruits juice are not. Calcium: Normally calcium intake with diet does not exceed 1.2 g/day. A balanced consumption of dairy products is capable of reducing oxalate intestinal absorption and urinary excretion compared to low calcium diet, being protective for stone disease. Oxalate: The exact amount of oxalate contained in different foods is difficult to estimate for its variability, even in the same aliment. In addition, the amount of oxalate consumed was shown to be only a minor risk factor for stone disease, whereas its intestinal absorption is strongly influenced by external factors, such as calcium intake. Dietary oxalate restriction is advisable only in patients with known elevated consumption. Sodium: High sodium intake is both associated with hypertension, heart disease and stone risk. Increased sodium consumption is directly associated to hypercalciuria in both calcium stone formers and healthy subjects. Although dietary sodium restriction to recommended values is always desirable in stone formers, it is difficult to achieve for its broad use in food preparation. Proteins: Animal proteins are associated to increased risk for stone formation, whereas vegetable and dairy proteins are not. Increased meat intake was associated to acidic urine pH, negative calcium balance and reduced anti-lithogenic urinary solutes excretion.Fruits and vegetables: Alkalizing foods are one of the most important factors for stone protection. Their consumption increases anti-lithogenic solutes as citrate, potassium and magnesium. A diet rich in fruits and vegetables is strongly recommended for stone formers. Uric acid: Elevated meat consumption is either associated to increased purine metabolism and acid load, favoring uric acid nephrolithiasis by reducing urine pH and increasing urinary excretion of uric acid, especially in patients affected by metabolic syndrome and diabetes.In conclusion, the most effective diet for stone protection is rich in fruits and vegetables, low in animal proteins and salt, with balanced dairy product consumption and obviously, with elevated fluid intake. These characteristics make vegetarian and Mediterranean diets protective and useful for stone formers, whereas western diet is at risk for stone formation.

摘要

营养与结石事件的风险密切相关。除了遗传易感性外,正确和均衡的饮食可能有助于预防肾结石的发生。有几项研究分析了每种饮食成分和不同的饮食,以更好地了解它们对结石复发的影响。

液体

高液体摄入是预防肾结石疾病最重要的因素,每增加 200 毫升水,结石的风险就降低 13%。软饮料似乎与更大的结石事件风险相关,而咖啡因和柑橘类果汁则不然。

正常情况下,饮食中的钙摄入量不超过 1.2 克/天。与低钙饮食相比,均衡摄入乳制品能够减少草酸的肠道吸收和尿排泄,对结石疾病具有保护作用。

草酸

不同食物中草酸的确切含量因变异性难以估计,即使在同一食物中也是如此。此外,草酸的摄入量仅被证明是结石疾病的一个较小风险因素,而其肠道吸收受到钙摄入量等外部因素的强烈影响。只有在已知草酸摄入量较高的患者中才建议限制饮食中的草酸。

高钠摄入与高血压、心脏病和结石风险有关。高钠摄入与钙结石形成者和健康受试者的高钙尿症直接相关。尽管建议结石形成者限制饮食中的钠摄入到推荐值,但由于其在食品制备中的广泛应用,这很难实现。

蛋白质

动物蛋白与结石形成的风险增加有关,而植物蛋白和奶制品蛋白则不然。增加肉类摄入与酸性尿 pH 值、负钙平衡和减少抗结石尿溶质排泄有关。

水果和蔬菜

碱性食物是结石保护的最重要因素之一。它们的摄入增加了柠檬酸盐、钾和镁等抗结石溶质。建议结石形成者多吃水果和蔬菜。

尿酸

肉类摄入增加与嘌呤代谢和酸负荷增加有关,通过降低尿 pH 值和增加尿酸排泄,特别是在患有代谢综合征和糖尿病的患者中,有利于尿酸肾结石的形成。

总之,预防结石最有效的饮食是富含水果和蔬菜、低动物蛋白和盐,摄入均衡的乳制品,当然还有大量液体。这些特点使素食和地中海饮食对结石形成者具有保护作用,而西方饮食则存在结石形成的风险。

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