The Framingham Heart Study, Framingham, MA, USA.
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
J Alzheimers Dis. 2021;79(4):1451-1457. doi: 10.3233/JAD-200545.
Because of their roles as potential risk factors, we evaluated whether obstructive sleep apnea (OSA) severity interacts with interleukin-6 (IL-6) in predicting incident dementia of the Alzheimer's type (DAT). In 269 dementia-free participants, IL-6 and the apnea-hypopnea index (AHI) were measured at baseline and incident DAT was surveilled for up to 22.8 years. Cox models revealed a significant interaction: In the lowest IL-6 quartile only, a higher AHI was associated with an elevated risk of DAT. The association between OSA severity and incident DAT might be especially apparent in the absence of inflammation or absence of potential benefits from IL-6.
由于它们作为潜在风险因素的作用，我们评估了阻塞性睡眠呼吸暂停（OSA）严重程度是否与白细胞介素-6（IL-6）相互作用，从而预测阿尔茨海默病型痴呆（DAT）的发病情况。在 269 名无痴呆的参与者中，在基线时测量了 IL-6 和呼吸暂停低通气指数（AHI），并对 DAT 的发病情况进行了长达 22.8 年的监测。Cox 模型显示出显著的相互作用：仅在 IL-6 四分位最低的情况下，较高的 AHI 与 DAT 的发病风险升高相关。OSA 严重程度与 DAT 发病之间的关联在没有炎症或没有 IL-6 的潜在获益的情况下可能尤为明显。
