睡眠不足与阿尔茨海默病：治疗方法的潜在途径
Insufficient Sleep and Alzheimer's Disease: Potential Approach for Therapeutic Treatment Methods.
作者信息
Trinh Dieu Quynh, Mai Nhu Huynh, Pham Toan Duc
机构信息
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam.
Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam.
出版信息
Brain Sci. 2024 Dec 28;15(1):21. doi: 10.3390/brainsci15010021.
Abstract
The interaction between Alzheimer's disease (AD) and sleep deprivation has recently gained attention in the scientific literature, and recent advances suggest that AD epidemiology management should coincide with the management of sleeping disorders. This review focuses on the aspects of the mechanisms underlying the link between AD and insufficient sleep with progressing age. We also provide information which could serve as evidence for future treatments of AD from the early stages in connection with sleep disorder medication.
摘要
阿尔茨海默病（AD）与睡眠剥夺之间的相互作用最近在科学文献中受到关注，并且最近的进展表明，AD的流行病学管理应与睡眠障碍的管理同步进行。这篇综述聚焦于随着年龄增长，AD与睡眠不足之间联系的潜在机制方面。我们还提供了一些信息，这些信息可以作为未来从AD早期阶段结合睡眠障碍药物治疗的证据。
相似文献
1
Insufficient Sleep and Alzheimer's Disease: Potential Approach for Therapeutic Treatment Methods.睡眠不足与阿尔茨海默病：治疗方法的潜在途径
Brain Sci. 2024 Dec 28;15(1):21. doi: 10.3390/brainsci15010021.
2
Sleep deprivation: A risk factor for the pathogenesis and progression of Alzheimer's disease.睡眠剥夺：阿尔茨海默病发病机制和进展的一个风险因素。
Heliyon. 2024 Apr 5;10(7):e28819. doi: 10.1016/j.heliyon.2024.e28819. eCollection 2024 Apr 15.
3
The interaction between orexin, sleep deprivation and Alzheimer's disease: Unveiling an Emerging Connection.食欲素、睡眠剥夺与阿尔茨海默病之间的相互作用：揭示一种新出现的联系。
J Physiol Sci. 2025 Mar;75(1):100004. doi: 10.1016/j.jphyss.2024.100004. Epub 2025 Jan 2.
4
Circadian Rhythm and Alzheimer's Disease.昼夜节律与阿尔茨海默病
Med Sci (Basel). 2018 Jun 21;6(3):52. doi: 10.3390/medsci6030052.
5
Exploring Potential Mechanisms of Sleep Disorders in Alzheimer's Dementia: A Scoping Review.探索阿尔茨海默病性痴呆睡眠障碍的潜在机制：一项范围综述
Cureus. 2025 Jan 3;17(1):e76859. doi: 10.7759/cureus.76859. eCollection 2025 Jan.
6
Sleep Deprivation, a Link Between Post-Traumatic Stress Disorder and Alzheimer's Disease.睡眠剥夺，创伤后应激障碍与阿尔茨海默病之间的联系。
J Alzheimers Dis. 2021;79(4):1443-1449. doi: 10.3233/JAD-201378.
7
Sleep Disturbance and Alzheimer's Disease: The Glial Connection.睡眠障碍与阿尔茨海默病：神经胶质的关联。
Neurochem Res. 2022 Jul;47(7):1799-1815. doi: 10.1007/s11064-022-03578-0. Epub 2022 Mar 18.
8
Circadian and sleep dysfunction in Alzheimer's disease.阿尔茨海默病的昼夜节律和睡眠功能障碍。
Ageing Res Rev. 2020 Jul;60:101046. doi: 10.1016/j.arr.2020.101046. Epub 2020 Apr 16.
9
Sleep Disturbance as a Potential Modifiable Risk Factor for Alzheimer's Disease.睡眠障碍作为阿尔茨海默病潜在的可调节风险因素。
Int J Mol Sci. 2019 Feb 13;20(4):803. doi: 10.3390/ijms20040803.
10
The effect of insomnia on development of Alzheimer's disease.失眠对阿尔茨海默病发展的影响。
J Neuroinflammation. 2020 Oct 6;17(1):289. doi: 10.1186/s12974-020-01960-9.
本文引用的文献
1
Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery.间充质干细胞在神经退行性疾病治疗探索中的应用。
Regen Ther. 2024 Oct 30;26:981-989. doi: 10.1016/j.reth.2024.09.014. eCollection 2024 Jun.
2
Low intensity repetitive transcranial magnetic stimulation enhances remyelination by newborn and surviving oligodendrocytes in the cuprizone model of toxic demyelination.低强度重复经颅磁刺激增强了在氯化铜诱导的毒性脱髓鞘模型中新生和存活的少突胶质细胞的髓鞘再生。
Cell Mol Life Sci. 2024 Aug 12;81(1):346. doi: 10.1007/s00018-024-05391-0.
3
Melatonin: A potential nighttime guardian against Alzheimer's.褪黑素：对抗阿尔茨海默病的潜在夜间守护者。
Mol Psychiatry. 2025 Jan;30(1):237-250. doi: 10.1038/s41380-024-02691-6. Epub 2024 Aug 11.
4
Benzodiazepine use in relation to long-term dementia risk and imaging markers of neurodegeneration: a population-based study.苯二氮䓬类药物使用与长期痴呆风险和神经退行性变的影像学标志物的关系：一项基于人群的研究。
BMC Med. 2024 Jul 2;22(1):266. doi: 10.1186/s12916-024-03437-5.
5
Low-intensity repetitive transcranial magnetic stimulation is safe and well tolerated by people living with MS - outcomes of the phase I randomised controlled trial (TAURUS).低强度重复经颅磁刺激对多发性硬化症患者来说是安全且耐受性良好的——I期随机对照试验（TAURUS）的结果
Mult Scler J Exp Transl Clin. 2024 May 15;10(2):20552173241252571. doi: 10.1177/20552173241252571. eCollection 2024 Apr-Jun.
6
Repetitive transcranial magnetic stimulation as a treatment for Alzheimer's disease: A randomized placebo-controlled double-blind clinical trial.重复经颅磁刺激治疗阿尔茨海默病的随机安慰剂对照双盲临床试验。
Neurotherapeutics. 2024 Apr;21(3):e00331. doi: 10.1016/j.neurot.2024.e00331. Epub 2024 Feb 14.
7
The effect of light therapy on sleep disorders and psychobehavioral symptoms in patients with Alzheimer's disease: A meta-analysis.光照疗法对阿尔茨海默病患者睡眠障碍和精神行为症状的影响：一项荟萃分析。
PLoS One. 2023 Dec 6;18(12):e0293977. doi: 10.1371/journal.pone.0293977. eCollection 2023.
8
Circadian timing, melatonin and hippocampal volume in later-life adults.中老年人群的昼夜节律、褪黑素与海马体体积。
J Sleep Res. 2024 Aug;33(4):e14090. doi: 10.1111/jsr.14090. Epub 2023 Nov 8.
9
Mutant β-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy.突变β-肾上腺素能受体改善 REM 睡眠并减轻tau 病模型中小鼠 tau 积聚。
Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2221686120. doi: 10.1073/pnas.2221686120. Epub 2023 Apr 4.
10
Early prediction of Alzheimer's disease and related dementias using real-world electronic health records.利用真实世界的电子健康记录对阿尔茨海默病及相关痴呆症进行早期预测。
Alzheimers Dement. 2023 Aug;19(8):3506-3518. doi: 10.1002/alz.12967. Epub 2023 Feb 23.
Zotero 插件