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经皮器械治疗时代急性心肌梗死伴难治性心原性休克的临时外科心室辅助装置。

Temporary surgical ventricular assist device for treatment of acute myocardial infarction and refractory cardiogenic shock in the percutaneous device era.

机构信息

Department of Surgery, Division of Cardiothoracic Surgery, Columbia University Medical Center, 177 Fort Washington Avenue, New York, NY, 10032, USA.

Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY, USA.

出版信息

J Artif Organs. 2021 Jun;24(2):199-206. doi: 10.1007/s10047-020-01236-2. Epub 2021 Jan 18.

Abstract

BACKGROUND

Acute myocardial infarction with refractory cardiogenic shock (AMI-RCS) is associated with poor outcomes. Several percutaneous mechanical circulatory support devices exist; however, limitations exist regarding long-term use. Herein, we describe our experience with the temporary surgical CentriMag VAD.

METHODS

We reviewed 74 patients with AMI-RCS who underwent CentriMag VAD insertion as bridge-to-decision device from 2007 to 2020. Patients were divided into groups based on introduction of the "shock team" model: Era 1 (2007-2014, n = 51) and Era 2 (2015-2020, n = 23).

RESULTS

Era 2 had higher proportion of patients with INTERMACS Profile I. The use of percutaneous MCS as bridge to VAD and the use of minimally invasive VAD were higher in Era 2. There were fewer postoperative bleeding events in Era 2 (80% vs 61%, p = .07). Thirty-day mortality was 23% and 1-year survival was 55%, which were no differences between eras. Destinations after CentriMag VAD included myocardial recovery (39%), durable LVAD (27%), and transplantation (5%).

CONCLUSION

CentriMag VAD device represents a viable bridge-to-decision device with acceptable short- and long-term outcomes for patients with AMI-RCS. Stable outcomes in a progressively sicker population may be related to changes in practice patterns as well as introduction of the "shock team" concept.

摘要

背景

急性心肌梗死伴难治性心源性休克(AMI-RCS)与不良预后相关。目前已有多种经皮机械循环支持设备,但长期应用存在局限性。在此,我们介绍了我们使用临时外科 CentriMag VAD 的经验。

方法

我们回顾了 2007 年至 2020 年期间 74 例因 AMI-RCS 而行 CentriMag VAD 置入作为桥接决策装置的患者。患者根据引入“休克团队”模式分为两组:时代 1(2007-2014 年,n=51)和时代 2(2015-2020 年,n=23)。

结果

时代 2 患者中 INTERMACS 分级 I 的比例更高。时代 2 中经皮 MCS 桥接至 VAD 和微创 VAD 的使用率更高。时代 2 的术后出血事件更少(80% vs 61%,p=0.07)。30 天死亡率为 23%,1 年生存率为 55%,两个时代之间无差异。CentriMag VAD 后的去向包括心肌恢复(39%)、耐用性 LVAD(27%)和移植(5%)。

结论

CentriMag VAD 装置为 AMI-RCS 患者提供了一种可行的桥接决策装置,具有可接受的短期和长期结果。在病情逐渐恶化的患者中,稳定的结果可能与实践模式的改变以及引入“休克团队”概念有关。

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