Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
Food Chem Toxicol. 2021 Mar;149 Suppl 1:111987. doi: 10.1016/j.fct.2021.111987. Epub 2021 Jan 15.
The existing information supports the use of this material as described in this safety assessment. 2-Mercaptopropionic acid was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 2-mercaptopropionic acid is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 2-mercaptopropionic acid is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the Dermal Sensitization Threshold (DST) for reactive materials (64 μg/cm); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; 2-mercaptopropionic acid is not expected to be phototoxic/photoallergenic. For the hazard assessment based on the screening data, 2-mercaptopropionic acid is not persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. For the risk assessment, 2-mercaptopropionic acid was not able to be risk screened as there were no reported volumes of use for either North America or Europe in the 2015 IFRA Survey.
现有信息支持将该材料用于本安全评估中所述用途。已对 2-巯基丙酸进行遗传毒性、重复剂量毒性、生殖毒性、局部呼吸毒性、光毒性/光变应原性、皮肤致敏性和环境安全性评估。数据表明 2-巯基丙酸没有遗传毒性。重复剂量、生殖和局部呼吸毒性终点是使用具有 I 类 Cramer 分类的毒性关注阈值（TTC）进行评估的，2-巯基丙酸的暴露量低于 TTC（分别为 0.03mg/kg/天、0.03mg/kg/天和 1.4mg/天）。皮肤致敏性终点是使用反应性物质的皮肤致敏性阈值（DST）完成的（64μg/cm）；暴露量低于 DST。光毒性/光变应原性终点是基于紫外线（UV）光谱进行评估的；预计 2-巯基丙酸没有光毒性/光变应原性。根据筛选数据进行的危害评估，根据国际香料协会（IFRA）环境标准，2-巯基丙酸不是持久性、生物累积性和毒性（PBT）物质。对于风险评估，由于在 2015 年 IFRA 调查中未报告北美或欧洲的任何使用量，因此无法对 2-巯基丙酸进行风险筛选。
