PM 暴露对循环纤维蛋白原和 IL-6 水平的影响：系统评价和荟萃分析。
Effect of PM exposure on circulating fibrinogen and IL-6 levels: A systematic review and meta-analysis.
机构信息
Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center of Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Department of Occupational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China.
出版信息
Chemosphere. 2021 May;271:129565. doi: 10.1016/j.chemosphere.2021.129565. Epub 2021 Jan 7.
BACKGROUND
Ambient fine particulate matter (PM) pollution poses a great threat on global health. Previous studies have reported that PM regulates circulating fibrinogen and IL-6 levels in the development of cardiovascular and respiratory disease. However, the correlation between PM exposure and both biomarkers remains inconsistent.
METHODS
We searched related articles through PubMed, Web of Science and ScienceDirect. Random effects model was used to obtain a pooled estimate effect of both biomarkers as PM concentration increased by every 10 μg/m. Meta-regression analysis, sensitivity analysis and publication bias test were conducted to evaluate the heterogeneity, stability and reliability of this meta-analysis.
RESULTS
A total of 22 articles were included. Each 10 μg/m increase in PM concentration was significantly correlated with a 1.76% increase in circulating fibrinogen level (95% CI: 0.38%-3.14%, P = 0.013) and a 4.66% increase in IL-6 level (95% CI: 1.14%-8.18%, P = 0.010). Subgroup analysis revealed that high-level PM exposure had a more significant association with circulating IL-6 level (11.67%, 95% CI: 0.66%-22.69%, P = 0.038) than low-level exposure, but this association was not observed in fibrinogen (2.50%, 95% CI: -0.78%-5.77%, P = 0.135). Sensitivity analysis and publication bias test confirmed the stability of the results.
CONCLUSION
Circulating fibrinogen and IL-6 significantly increased with exposure to PM, may serve as promising biomarkers for PM-related adverse effects.
背景
环境细颗粒物（PM）污染对全球健康构成了巨大威胁。先前的研究报告称，PM 可调节心血管和呼吸道疾病发展过程中的循环纤维蛋白原和 IL-6 水平。然而，PM 暴露与这两种生物标志物之间的相关性仍然不一致。
方法
我们通过 PubMed、Web of Science 和 ScienceDirect 搜索相关文章。使用随机效应模型，得出当 PM 浓度每增加 10μg/m 时，两种生物标志物的综合估计效应。进行元回归分析、敏感性分析和发表偏倚检验，以评估该荟萃分析的异质性、稳定性和可靠性。
结果
共纳入 22 篇文章。PM 浓度每增加 10μg/m，与循环纤维蛋白原水平升高 1.76%（95%CI：0.38%-3.14%，P=0.013）和 IL-6 水平升高 4.66%（95%CI：1.14%-8.18%，P=0.010）显著相关。亚组分析显示，高水平 PM 暴露与循环 IL-6 水平的相关性更为显著（11.67%，95%CI：0.66%-22.69%，P=0.038），而与低水平暴露的相关性则不明显，但在纤维蛋白原中并未观察到这种相关性（2.50%，95%CI：-0.78%-5.77%，P=0.135）。敏感性分析和发表偏倚检验证实了结果的稳定性。
结论
循环纤维蛋白原和 IL-6 随 PM 暴露显著增加，可能作为与 PM 相关的不良影响的有前途的生物标志物。
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