婴儿因掺假千里光而导致的致命吡咯里西啶生物碱中毒。

Fatal pyrrolizidine alkaloid poisoning of infants caused by adulterated Senecio coronatus.

机构信息

Mass Spectrometry Unit, Central Analytical Facility, University of Stellenbosch, Private Bag X1, Matieland, 7600, South Africa.

Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland, 7600, South Africa; Mass Spectrometry Unit, Central Analytical Facility, University of Stellenbosch, Private Bag X1, Matieland, 7600, South Africa.

出版信息

Forensic Sci Int. 2021 Mar;320:110680. doi: 10.1016/j.forsciint.2020.110680. Epub 2020 Dec 31.

DOI:10.1016/j.forsciint.2020.110680

PMID:33461004

Abstract

Senecio coronatus (known as izonkozonko and ubulibazi in Zulu) is commonly used in traditional medicine in South Africa as purification purgative and enemas for infants during weaning. We show for the first time that this species does not contain pyrrolizidine alkaloids and that reported cases of fatal hepatic sinusoidal obstruction syndrome in infants were caused by wrongly identified Senecio species containing large amounts of retrorsine-N-oxide. A validated ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection and quantitation of pyrrolizidine alkaloids is described.

摘要

南非泽兰（在祖鲁语中被称为 izonkozonko 和 ubulibazi）通常在南非传统医学中被用作净化剂、泻药和断奶婴儿的灌肠剂。我们首次表明，该物种不含吡咯里西啶生物碱，并且先前报道的婴儿致命性肝窦阻塞综合征病例是由误识别的含有大量 retrorsine-N-oxide 的泽兰属物种引起的。本文描述了一种经过验证的超高效液相色谱串联质谱（UPLC-MS/MS）方法，用于检测和定量吡咯里西啶生物碱。