Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Wuhan Children's Hospital, Wuhan, Hubei, People's Republic of China.
J Hazard Mater. 2021 Jun 5;411:125102. doi: 10.1016/j.jhazmat.2021.125102. Epub 2021 Jan 11.
Prenatal vanadium exposure is reported to be associated with restricted fetal growth and adverse birth outcomes. However, trimester-specific vanadium exposure in relation to early-childhood growth still remains unclear. A total of 1873 Chinese mother-infant pairs from whom a complete series of maternal urinary samples were collected over three stages of pregnancy were included from 2014 to 2016. The urinary concentrations of vanadium were analyzed. Children's anthropometric parameters were measured at birth, 6, 12 and 24 months. In boys, each doubling increase in vanadium concentrations at middle pregnancy was inversely associated with weight-for-length [- 9.07% (-17.21%, -0.93%)] and BMI z-score [- 9.66% (-18.05%, -1.28%)] at 24 months. Moreover, vanadium exposure at late pregnancy was negatively associated with weight [- 9.85% (-16.42%, -3.28%)], weight-for-length [- 11.00% (-18.40%, -3.60%)], and BMI z-scores [- 11.05% (-18.67%, -3.42%)] at 24 months in boys. However, the negative associations were not observed in girls, and we found evidence for sex difference (FDR p for interaction=0.01, 0.01 and 0.03 for weight, weight-for-length and BMI z-scores, respectively). Prenatal vanadium exposure may have an adverse effect on early-childhood growth, and the middle and late pregnancy could be windows of vulnerability for the adverse effects of vanadium exposure on growth development.
孕期钒暴露与胎儿生长受限和不良出生结局有关。然而，与儿童早期生长相关的妊娠特定时期钒暴露仍不清楚。2014 年至 2016 年期间，共纳入了 1873 对中国母婴对子，这些母婴在妊娠的三个阶段均采集了完整的一系列尿液样本。分析了尿液中钒的浓度。在出生、6、12 和 24 个月时测量了儿童的人体测量参数。在男孩中，妊娠中期钒浓度每增加一倍，与 24 个月时的身长体重比[-9.07%（-17.21%，-0.93%）]和 BMI z 评分[-9.66%（-18.05%，-1.28%）]呈负相关。此外，妊娠晚期的钒暴露与男孩 24 个月时的体重[-9.85%（-16.42%，-3.28%）]、身长体重比[-11.00%（-18.40%，-3.60%）]和 BMI z 评分[-11.05%（-18.67%，-3.42%）]呈负相关。然而，在女孩中没有观察到这种负相关，并且我们发现了性别差异的证据（FDR p 交互作用分别为 0.01、0.01 和 0.03，用于体重、身长体重比和 BMI z 评分）。孕期钒暴露可能对儿童早期生长有不良影响，妊娠中期和晚期可能是钒暴露对生长发育产生不良影响的脆弱窗口。
