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牵牛花盘状异常相关黄斑病变:多模态成像

Morning glory disc anomaly-associated maculopathy: multimodal imaging.

作者信息

Hwang Inae, Ugarte Marta

机构信息

The University of Manchester, Faculty of Biology, Medicine and Health, Manchester, Greater Manchester, UK.

The University of Manchester, Faculty of Biology, Medicine and Health, Manchester, Greater Manchester, UK

出版信息

BMJ Case Rep. 2021 Jan 18;14(1):e237462. doi: 10.1136/bcr-2020-237462.

Abstract

Morning glory disc anomaly (MGDA) is most commonly found in white females in childhood with reduced vision. One in two cases have been reported to develop maculopathy or posterior pole retinal detachment as they grow older. The pathophysiology of MGDA-associated maculopathy is not well understood.We describe a 31-year-old black woman, who presented with gradual reduction of vision in the right eye due to MGDA-associated maculopathy. We identified morphological characteristics of the optic disc and macula with multicolour and optical coherence tomography imaging.We speculate that the centripetal inner retina traction and cerebrospinal fluid pressure fluctuation play an important role in inner retinal fluid accumulation in the pathology of retinoschisis in MGDA. Further studies will shed some light of a potential cause-and-effect relationship between MGDA and retinoschisis.

摘要

牵牛花盘状异常(MGDA)最常见于儿童期视力下降的白人女性。据报道,每两例病例中就有一例在长大后会发展为黄斑病变或后极视网膜脱离。MGDA相关黄斑病变的病理生理学尚未完全了解。我们描述了一名31岁的黑人女性,她因MGDA相关黄斑病变出现右眼视力逐渐下降。我们通过多色和光学相干断层扫描成像确定了视盘和黄斑的形态特征。我们推测,向心性视网膜内层牵引和脑脊液压力波动在MGDA视网膜劈裂症的病理过程中,对视网膜内层积液起着重要作用。进一步的研究将有助于揭示MGDA与视网膜劈裂症之间潜在的因果关系。

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