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Incidental finding of regressed solitary unilateral choroidal metastasis from lung adenocarcinoma with EGFR exon-19 deletion treated with erlotinib.偶然发现的肺腺癌伴表皮生长因子受体(EGFR)外显子19缺失的单侧孤立性脉络膜转移灶经厄洛替尼治疗后消退。
BMJ Case Rep. 2021 Jan 18;14(1):e238131. doi: 10.1136/bcr-2020-238131.
2
Erlotinib as first line treatment in a NSCLC patient with choroidal metastasis and with EGFR exon 19 deletion.厄洛替尼作为一名患有脉络膜转移且伴有表皮生长因子受体第19外显子缺失的非小细胞肺癌患者的一线治疗药物。
J BUON. 2016 May-Jun;21(3):754-5.
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A case of choroidal metastasis of lung cancer successfully treated with erlotinib.一例成功使用厄洛替尼治疗的肺癌脉络膜转移病例。
Gan To Kagaku Ryoho. 2012 Feb;39(2):269-71.
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Response to Erlotinib in a Patient with Compound EGFR L747S and Exon 19 Deletion.一名患有EGFR L747S复合突变和19外显子缺失患者对厄洛替尼的反应
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Choroidal metastasis with adenocarcinoma of the lung treated with gefitinib.吉非替尼治疗肺腺癌脉络膜转移
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[Choroid metastases revealing pulmonary adenocarcioma resolved with chemotherapy].[化疗使脉络膜转移癌所揭示的肺腺癌病情缓解]
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Choroidal metastases from lung adenocarcinoma.肺腺癌的脉络膜转移。
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SIMULTANEOUS CHOROIDAL AND RETINAL METASTASES FROM LUNG CARCINOMA.肺癌同时发生脉络膜和视网膜转移
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本文引用的文献

1
New concepts in the diagnosis and management of choroidal metastases.脉络膜转移瘤的诊断和治疗新概念。
Prog Retin Eye Res. 2019 Jan;68:144-176. doi: 10.1016/j.preteyeres.2018.09.003. Epub 2018 Sep 19.
2
Tyrosine Kinase Inhibitors in the Treatment of Choroidal Metastases from Non-Small-Cell Lung Cancer: A Case Report and Review of Literature.酪氨酸激酶抑制剂治疗非小细胞肺癌脉络膜转移:一例报告并文献复习
Ocul Oncol Pathol. 2017 Jan;3(1):28-33. doi: 10.1159/000448114. Epub 2016 Sep 14.
3
Choroidal metastases: origin, features, and therapy.脉络膜转移瘤:起源、特征及治疗
Indian J Ophthalmol. 2015 Feb;63(2):122-7. doi: 10.4103/0301-4738.154380.
4
Rapid regression of choroidal metastasis from lung cancer using erlotinib (Tarceva).使用厄洛替尼(特罗凯)使肺癌脉络膜转移快速消退
Oman J Ophthalmol. 2014 May;7(2):75-7. doi: 10.4103/0974-620X.137159.
5
Enhanced depth imaging optical coherence tomography of choroidal metastasis in 14 eyes.14只眼脉络膜转移瘤的增强深度成像光学相干断层扫描
Retina. 2014 Aug;34(8):1588-93. doi: 10.1097/IAE.0000000000000131.
6
Autofluorescence of intraocular tumours.眼内肿瘤的自发荧光。
Curr Opin Ophthalmol. 2013 May;24(3):222-32. doi: 10.1097/ICU.0b013e32835f8ba1.
7
Autofluorescence of metastatic choroidal tumor.转移性脉络膜肿瘤的自发荧光。
Int Ophthalmol. 2009 Aug;29(4):309-13. doi: 10.1007/s10792-008-9234-2. Epub 2008 Jun 5.
8
Solitary choroidal metastasis managed by transpupillary thermotherapy.
Eye (Lond). 2000 Oct;14 Pt 5:799-800. doi: 10.1038/eye.2000.215.
9
Survey of 520 eyes with uveal metastases.520例葡萄膜转移瘤患者的调查。
Ophthalmology. 1997 Aug;104(8):1265-76. doi: 10.1016/s0161-6420(97)30148-1.

偶然发现的肺腺癌伴表皮生长因子受体(EGFR)外显子19缺失的单侧孤立性脉络膜转移灶经厄洛替尼治疗后消退。

Incidental finding of regressed solitary unilateral choroidal metastasis from lung adenocarcinoma with EGFR exon-19 deletion treated with erlotinib.

作者信息

Padhy Srikanta Kumar, Kaliki Swathi

机构信息

Retina, Uvea and ROP Services, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Orissa, India.

Ocular Oncology, LV Prasad Eye Institute, Hyderabad, Telangana, India

出版信息

BMJ Case Rep. 2021 Jan 18;14(1):e238131. doi: 10.1136/bcr-2020-238131.

DOI:10.1136/bcr-2020-238131
PMID:33462020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7816960/
Abstract

A 49-year-old Asian Indian woman, with a previous history of biopsy proven stage IV primary lung adenocarcinoma with metastasis to liver, bones and central nervous system, presented with 1-month history of photopsia in right eye. She was on oral erlotinib since 6 months. Dilated fundus examination of right eye revealed a solitary dome-shaped brownish elevated lesion of approximately 1-disc diameter along the inferotemporal midperiphery with surrounding areas of hypopigmentation. Based on multimodal imaging, a diagnosis of resolved solitary unilateral choroidal metastasis from lung carcinoma in the right eye was made. In view of inactive and regressed choroidal metastasis, no intervention was mandated.

摘要

一名49岁的亚洲印度女性,既往活检证实为IV期原发性肺腺癌,已转移至肝脏、骨骼和中枢神经系统,现因右眼有1个月的闪光幻觉病史前来就诊。她已经口服厄洛替尼6个月。右眼散瞳眼底检查发现,在颞下中周边部有一个孤立的圆顶状褐色隆起病变,直径约1个视盘大小,周围有色素减退区。基于多模态成像,诊断为右眼已消退的孤立性单侧脉络膜肺癌转移。鉴于脉络膜转移处于静止和消退状态,未采取干预措施。