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偶然发现的肺腺癌伴表皮生长因子受体(EGFR)外显子19缺失的单侧孤立性脉络膜转移灶经厄洛替尼治疗后消退。

Incidental finding of regressed solitary unilateral choroidal metastasis from lung adenocarcinoma with EGFR exon-19 deletion treated with erlotinib.

作者信息

Padhy Srikanta Kumar, Kaliki Swathi

机构信息

Retina, Uvea and ROP Services, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Orissa, India.

Ocular Oncology, LV Prasad Eye Institute, Hyderabad, Telangana, India

出版信息

BMJ Case Rep. 2021 Jan 18;14(1):e238131. doi: 10.1136/bcr-2020-238131.

Abstract

A 49-year-old Asian Indian woman, with a previous history of biopsy proven stage IV primary lung adenocarcinoma with metastasis to liver, bones and central nervous system, presented with 1-month history of photopsia in right eye. She was on oral erlotinib since 6 months. Dilated fundus examination of right eye revealed a solitary dome-shaped brownish elevated lesion of approximately 1-disc diameter along the inferotemporal midperiphery with surrounding areas of hypopigmentation. Based on multimodal imaging, a diagnosis of resolved solitary unilateral choroidal metastasis from lung carcinoma in the right eye was made. In view of inactive and regressed choroidal metastasis, no intervention was mandated.

摘要

一名49岁的亚洲印度女性,既往活检证实为IV期原发性肺腺癌,已转移至肝脏、骨骼和中枢神经系统,现因右眼有1个月的闪光幻觉病史前来就诊。她已经口服厄洛替尼6个月。右眼散瞳眼底检查发现,在颞下中周边部有一个孤立的圆顶状褐色隆起病变,直径约1个视盘大小,周围有色素减退区。基于多模态成像,诊断为右眼已消退的孤立性单侧脉络膜肺癌转移。鉴于脉络膜转移处于静止和消退状态,未采取干预措施。

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