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本文引用的文献

1
Waning of Measured Influenza Vaccine Effectiveness Over Time: The Potential Contribution of Leaky Vaccine Effect.随时间推移测量的流感疫苗效力下降：漏接疫苗效应的潜在贡献。
Clin Infect Dis. 2020 Dec 17;71(10):e633-e641. doi: 10.1093/cid/ciaa340.
2
Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices - United States, 2019-20 Influenza Season.季节性流感疫苗预防和控制：免疫实践咨询委员会的建议 - 美国，2019-20 流感季。
MMWR Recomm Rep. 2019 Aug 23;68(3):1-21. doi: 10.15585/mmwr.rr6803a1.
3
Depletion-of-susceptibles Bias in Analyses of Intra-season Waning of Influenza Vaccine Effectiveness.分析流感疫苗效果在季节内衰减时的易感者偏倚。
Clin Infect Dis. 2020 Mar 17;70(7):1484-1486. doi: 10.1093/cid/ciz706.
4
Waning of Influenza Vaccine Protection: Exploring the Trade-offs of Changes in Vaccination Timing Among Older Adults.流感疫苗保护效果减弱：探索老年人接种时间变化的权衡取舍。
Clin Infect Dis. 2020 Apr 10;70(8):1550-1559. doi: 10.1093/cid/ciz452.
5
Prevention of Influenza Hospitalization Among Adults in the United States, 2015-2016: Results From the US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN).美国成人流感住院预防，2015-2016 年：来自美国成人住院流感疫苗有效性网络（HAIVEN）的结果。
J Infect Dis. 2019 Sep 13;220(8):1265-1275. doi: 10.1093/infdis/jiy723.
6
Duration of Influenza Vaccine Effectiveness: A Systematic Review, Meta-analysis, and Meta-regression of Test-Negative Design Case-Control Studies.流感疫苗有效性持续时间：基于病例对照研究的系统评价、荟萃分析和荟萃回归的阴性测试设计。
J Infect Dis. 2018 Feb 14;217(5):731-741. doi: 10.1093/infdis/jix632.
7
Intraseason waning of influenza vaccine protection: Evidence from the US Influenza Vaccine Effectiveness Network, 2011-12 through 2014-15.流感疫苗保护作用的季节性减弱：来自美国流感疫苗有效性网络的证据，2011-12 至 2014-15 年。
Clin Infect Dis. 2017 Mar 1;64(5):544-550. doi: 10.1093/cid/ciw816. Epub 2016 Dec 29.
8
Modest Waning of Influenza Vaccine Efficacy and Antibody Titers During the 2007-2008 Influenza Season.2007-2008 流感季节期间流感疫苗效力和抗体滴度的适度降低。
J Infect Dis. 2016 Oct 15;214(8):1142-9. doi: 10.1093/infdis/jiw105. Epub 2016 Apr 19.
9
Waning vaccine protection against influenza A (H3N2) illness in children and older adults during a single season.在单个季节中，儿童和老年人针对甲型流感（H3N2）疾病的疫苗保护作用逐渐减弱。
Vaccine. 2015 Jan 1;33(1):246-51. doi: 10.1016/j.vaccine.2014.06.052. Epub 2014 Jun 21.
10
Immunity in Human Subjects Artificially Infected with Influenza Virus, Type B.人工感染B型流感病毒的人体免疫力
Am J Public Health Nations Health. 1944 Apr;34(4):317-34. doi: 10.2105/ajph.34.4.317.

2015-2016 年至 2018-2019 年美国住院成人流感疫苗有效性网络：成人因流感相关住院的疫苗有效性逐渐降低。

Waning Vaccine Effectiveness Against Influenza-Associated Hospitalizations Among Adults, 2015-2016 to 2018-2019, United States Hospitalized Adult Influenza Vaccine Effectiveness Network.

机构信息

Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Baylor Scott & White Health System, Temple, Texas, USA.

出版信息

Clin Infect Dis. 2021 Aug 16;73(4):726-729. doi: 10.1093/cid/ciab045.

DOI:10.1093/cid/ciab045
PMID:33462610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8499703/
Abstract

We observed decreased effectiveness of influenza vaccine with increasing time since vaccination for prevention of influenza A(H3N2), influenza A(H1N1)pdm09, and influenza B/Yamagata-associated hospitalizations among adults. Maximum vaccine effectiveness (VE) was observed shortly after vaccination, followed by an absolute decline in VE of about 8%-9% per month postvaccination.

摘要

我们观察到，随着接种流感疫苗后时间的延长，流感疫苗预防 A(H3N2)、A(H1N1)pdm09 和 B/Yamagata 型流感相关住院的效果下降。接种后短期内疫苗效果最佳，随后每月疫苗效果绝对下降约 8%-9%。