Aloe L
Istituto di Neurobiologia, C.N.R., Rome, Italy.
J Neuroimmunol. 1988 Apr;18(1):1-12. doi: 10.1016/0165-5728(88)90129-4.
Repeated subcutaneous administration of nerve growth factor (NGF) into newborn rats caused an increase in number and size of free and tissue-adherent mast cells (MCs). In vivo and in vitro autoradiographic studies show that MCs exhibit specific binding sites for NGF. Peritoneal MCs of adult rats exposed to high titers of endogenous (autoimmunization) and exogenous NGF antibodies showed severe cytological alterations and decreased in number. Light and electron microscopic studies revealed that MC destruction took place slowly (7-10 days) and required continual exposure to high titers of NGF antibodies. The role played by NGF in the hematopoietic cell lineage is at present under study in our laboratory.
对新生大鼠反复进行皮下注射神经生长因子（NGF），会导致游离型和组织黏附型肥大细胞（MCs）的数量增加、体积增大。体内和体外放射自显影研究表明，MCs表现出NGF的特异性结合位点。成年大鼠的腹膜MCs在暴露于高滴度的内源性（自身免疫）和外源性NGF抗体后，出现了严重的细胞学改变且数量减少。光镜和电镜研究显示，MCs的破坏过程较为缓慢（7 - 10天），且需要持续暴露于高滴度的NGF抗体。目前，我们实验室正在研究NGF在造血细胞谱系中所起的作用。
