Department of Internal Medicine.
OCON, Center for Orthopaedic Surgery, Hengelo, The Netherlands.
Rheumatology (Oxford). 2021 Jul 1;60(7):3409-3412. doi: 10.1093/rheumatology/keaa697.
The role of vitamin D in OA is unclear and previous epidemiological studies have provided inconsistent results. We conducted a two-sample Mendelian randomization (MR) study to investigate the causal relationship between genetically determined serum vitamin D levels and hip/knee OA.
Six single-nucleotide polymorphisms (SNPs) associated with vitamin D levels in the Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits Consortium were selected as instrumental variables. Summary statistics of the SNPs effects on OA were derived from the Iceland and UK Biobank, comprising 23 877 knee OA cases, 17 151 hip OA cases and >562 000 controls. The control samples match the OA cases in age, sex and county of origin.
The MR analyses showed no causal association between genetically determined vitamin D levels and knee OA [odds ratio (OR) 1.03 (95% CI 0.84, 1.26)] or hip OA [OR 1.06 (95% CI 0.83, 1.35)].
Genetic variations associated with low vitamin D serum levels are not associated with increased risk of hip or knee OA in community-dwelling older adults, suggesting that vitamin D levels are not causally linked to OA. It is therefore unlikely that vitamin D supplementation protects against hip or knee OA.
维生素 D 与 OA 的关系尚不清楚，先前的流行病学研究结果也不一致。我们进行了两样本 Mendelian 随机化（MR）研究，以调查遗传决定的血清维生素 D 水平与髋/膝 OA 之间的因果关系。
选择与 Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits Consortium 中维生素 D 水平相关的 6 个单核苷酸多态性（SNP）作为工具变量。来自冰岛和英国生物银行的 SNP 对 OA 影响的汇总统计数据，包括 23 877 例膝 OA 病例、17 151 例髋 OA 病例和>562 000 例对照。对照样本在年龄、性别和原籍县方面与 OA 病例相匹配。
MR 分析表明，遗传决定的维生素 D 水平与膝 OA [比值比（OR）1.03（95%置信区间 0.84，1.26）]或髋 OA [OR 1.06（95%置信区间 0.83，1.35）]之间没有因果关系。
与低血清维生素 D 水平相关的遗传变异与社区居住的老年人群中髋或膝 OA 的风险增加无关，这表明维生素 D 水平与 OA 之间没有因果关系。因此，维生素 D 补充不太可能预防髋或膝 OA。
Zotero 插件