Department of Orthopedics, Wuhan Fourth Hospital, Qiaokou District, Wuhan, China.
Medicine (Baltimore). 2024 Oct 4;103(40):e40021. doi: 10.1097/MD.0000000000040021.
Previous studies on the relationship between vitamin D, sleep quality, and osteoarthritis (OA) have been controversial and the aim of this study is to analyze the association. In this study, relevant data from 2 survey cycles (2009-2010 with 2011-2012) are downloaded from the CDC's NHANES project to analyze the relationship between vitamin D, sleep quality, and osteoarthritis, as well as other related risk factors. The analysis of statistics in this study is performed using t-tests and chi-square tests, modeling is performed using logistic regression based on NHANES weights, and other risk factors are analyzed using forest plots. In association models between serum vitamin D, sleep quality, and OA is statistically significant during the stepwise inclusion of covariates. In model 1, Q3 (OR = 1.83; 95% CI: 1.05, 3.23) and Q4 (OR = 2.22; 95% CI: 1.27, 3.94) are significant. Neither model 2 nor model 3 is statistically significant and P for trend is more than .05 in all 3 models. After the inclusion of all covariates, forest plot showed that sleep deprivation (OR = 1.64; 95% CI: 1.05, 2.56), advanced age (OR = 1.03; 95% CI: 1.01, 1.04), female (OR = 1.79; 95% CI: 1.14, 2.85), overweight (25 ≤ BMI < 30) (OR = 1.92; 95% CI: 1.05, 3.61), and obesity (≥30) (OR = 2.06; 95% CI: 1.11, 3.93) are risk factors for OA. This study is based on a larger sample and a stepwise logistic regression of multiple covariates. We concluded that vitamin D may not influence OA. However other risk factors for OA are confirmed, including advanced age, female and high BMI, especially bad sleep quality.
先前关于维生素 D、睡眠质量和骨关节炎（OA）之间关系的研究结果存在争议，本研究旨在对此进行分析。本研究从 CDC 的 NHANES 项目中下载了两个调查周期（2009-2010 年和 2011-2012 年）的相关数据，以分析维生素 D、睡眠质量与 OA 之间的关系，以及其他相关的危险因素。本研究采用 t 检验和卡方检验进行统计学分析，基于 NHANES 权重进行逻辑回归建模，采用森林图分析其他危险因素。在逐步纳入协变量的情况下，血清维生素 D、睡眠质量与 OA 之间的关联模型具有统计学意义。在模型 1 中，Q3（OR=1.83；95%CI：1.05，3.23）和 Q4（OR=2.22；95%CI：1.27，3.94）具有统计学意义。模型 2 和模型 3 均无统计学意义，且 3 个模型的趋势 P 值均大于 0.05。在纳入所有协变量后，森林图显示睡眠不足（OR=1.64；95%CI：1.05，2.56）、年龄较大（OR=1.03；95%CI：1.01，1.04）、女性（OR=1.79；95%CI：1.14，2.85）、超重（25≤BMI<30）（OR=1.92；95%CI：1.05，3.61）和肥胖（BMI≥30）（OR=2.06；95%CI：1.11，3.93）是 OA 的危险因素。本研究基于更大的样本量和多个协变量的逐步逻辑回归分析。我们得出结论，维生素 D 可能不会影响 OA，但 OA 的其他危险因素，包括年龄较大、女性和高 BMI，特别是睡眠质量差，得到了确认。
