羧酸、醛或醇在氧化氟化条件下生成的酰氟。
Acyl Fluorides from Carboxylic Acids, Aldehydes, or Alcohols under Oxidative Fluorination.
机构信息
Department of Nanopharmaceutical Sciences and Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
Institute of Advanced Fluorine-Containing Materials, Zhejiang Normal University, 688 Yingbin Avenue, Jinhua 321004, China.
出版信息
Org Lett. 2021 Feb 5;23(3):847-852. doi: 10.1021/acs.orglett.0c04087. Epub 2021 Jan 19.
We describe a novel reagent system to obtain acyl fluorides directly from three different functional group precursors: carboxylic acids, aldehydes, or alcohols. The transformation is achieved via a combination of trichloroisocyanuric acid and cesium fluoride, which facilitates the synthesis of various acyl fluorides in high yield (up to 99%). It can be applied to the late-stage functionalization of natural products and drug molecules that contain a carboxylic acid, an aldehyde, or an alcohol group.
我们描述了一种从三种不同官能团前体（羧酸、醛或醇）直接获得酰氟的新型试剂系统。该转化通过三氯异氰尿酸和氟化铯的组合来实现，可高收率（高达 99%）合成各种酰氟。它可以应用于含有羧酸、醛或醇基团的天然产物和药物分子的后期功能化。
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