Department of Dermatology, Churchill Hospital, Oxford University NHS Foundation Trust, Oxford, United Kingdom ; and.
Department of Dermatopathology, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, United Kingdom .
Am J Dermatopathol. 2021 Aug 1;43(8):576-578. doi: 10.1097/DAD.0000000000001887.
Cutaneous reactive angiomatoses encompass a spectrum of conditions driven by underlying occlusive vasculopathy. We present 2 cases of reactive angioproliferation in the context of end-stage renal failure (ESRF) manifesting as painful cutaneous ulceration. The first case demonstrates histologic features of diffuse dermal angiomatosis. The second case illustrates a nonspecific pattern of vascular proliferation which does not conform to any of the classically described subtypes, therefore reinforcing the concept of a spectrum of histopathologic changes in reactive angioproliferations. Diffuse dermal angiomatosis has been described in ESRF alone and in association with calciphylaxis, a life-threatening condition. Recognizing the patterns of reactive angioproliferation in the context of ESRF therefore has clinical relevance. Earlier identification may facilitate mitigation of risk factors and improve prognosis.
皮肤反应性血管病变包括一系列由潜在闭塞性血管病变引起的疾病。我们提出 2 例终末期肾衰竭（ESRF）背景下表现为疼痛性皮肤溃疡的反应性血管增殖病例。第一个病例表现为弥漫性真皮血管瘤病的组织学特征。第二个病例显示出非特异性的血管增殖模式，不符合任何经典描述的亚型，因此强化了反应性血管增殖的组织病理学变化谱的概念。弥漫性真皮血管瘤病仅在 ESRF 中描述，也与危及生命的钙化醇症相关。因此，在 ESRF 背景下识别反应性血管增殖的模式具有临床意义。早期识别可能有助于减轻危险因素并改善预后。
