Yuan Pan, Ruan Zheng, Yan Lifeng
CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, and Department of Chemical Physics, University of Science and Technology of China, Jinzai Road 96, Hefei 230026, Anhui, P. R. China.
ACS Biomater Sci Eng. 2020 Feb 10;6(2):1043-1051. doi: 10.1021/acsbiomaterials.9b01662. Epub 2020 Jan 23.
Near-infrared (NIR) photodynamic therapy (PDT) is a promising antitumor strategy under NIR light irradiation to kill cancer cells. Mitochondria has a critical function in sustaining cellular viability and death, which is the ideal organelle for PDT. Here, we reported a tetraphenylporphine (TPP)-conjugated amphiphilic copolymer and an iodinated boron dipyrromethene photosensitizer (BDPI) with high singlet oxygen yield to form nanoparticles (PBDPI-TPP), which could realize mitochondria-targeting and improve the NIR imaging-guided PDT. The as-prepared mitochondria-targeting nanoplatform could show effective subcellular localization and bring about significant irreversible mitochondrial injury for enhanced PDT. Both in vitro and in vivo experiments revealed that the mitochondria-targeting PDT system could achieve a remarkable therapeutic effect, indicating that it is a promising nanoplatform for NIR imaging-guided PDT in cancer therapeutics.
近红外（NIR）光动力疗法（PDT）是一种在近红外光照射下杀死癌细胞的有前景的抗肿瘤策略。线粒体在维持细胞活力和死亡方面具有关键作用，是光动力疗法的理想细胞器。在此，我们报道了一种四苯基卟啉（TPP）共轭两亲共聚物和一种具有高单线态氧产率的碘化硼二吡咯亚甲基光敏剂（BDPI），以形成纳米颗粒（PBDPI-TPP），其可实现线粒体靶向并改善近红外成像引导的光动力疗法。所制备的线粒体靶向纳米平台可显示有效的亚细胞定位，并导致显著的不可逆线粒体损伤以增强光动力疗法。体外和体内实验均表明，线粒体靶向光动力疗法系统可实现显著的治疗效果，表明其是癌症治疗中近红外成像引导光动力疗法的一种有前景的纳米平台。
