用于肿瘤双光子荧光成像和光动力治疗的近红外光敏剂。

NIR Photosensitizer for Two-Photon Fluorescent Imaging and Photodynamic Therapy of Tumor.

作者信息

Chen Lujia, Chen Meijuan, Zhou Yuping, Ye Changsheng, Liu Ruiyuan

机构信息

Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Hepatology Unit and Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

出版信息

Front Chem. 2021 Feb 23;9:629062. doi: 10.3389/fchem.2021.629062. eCollection 2021.

DOI:10.3389/fchem.2021.629062

PMID:33708758

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7940671/

Abstract

Preparation of near-infrared (NIR) emissive fluorophore for imaging-guided PDT (photodynamic therapy) has attracted enormous attention. Hence, NIR photosensitizers of two-photon (TP) fluorescent imaging and photodynamic therapy are highly desirable. In this contribution, a novel D-π-A structured NIR photosensitizer (TTRE) is synthesized. TTRE demonstrates near-infrared (NIR) emission, good biocompatibility, and superior photostability, which can act as TP fluorescent agent for clear visualization of cells and vascular in tissue with deep-tissue penetration. The PDT efficacy of TTRE as photosensitizer is exploited and . All these results confirm that TTRE would serve as potential platform for TP fluorescence imaging and imaging-guided photodynamic therapy.

摘要

用于成像引导光动力疗法（PDT）的近红外（NIR）发射荧光团的制备引起了极大关注。因此，非常需要用于双光子（TP）荧光成像和光动力疗法的近红外光敏剂。在本论文中，合成了一种新型的D-π-A结构近红外光敏剂（TTRE）。TTRE表现出近红外（NIR）发射、良好的生物相容性和优异的光稳定性，可作为TP荧光剂用于清晰可视化具有深层组织穿透性的组织中的细胞和血管。研究了TTRE作为光敏剂的光动力疗法疗效。所有这些结果证实，TTRE将成为TP荧光成像和成像引导光动力疗法的潜在平台。