用于灵敏氟磁共振成像的肿瘤靶向超氟化胶束探针。
Tumor-targeted superfluorinated micellar probe for sensitive F-MRI.
作者信息
Jamgotchian Lucie, Vaillant Solenne, Selingue Erwan, Doerflinger Anaelle, Belime Agathe, Vandamme Marie, Pinna Guillaume, Ling Wai Li, Gravel Edmond, Mériaux Sébastien, Doris Eric
机构信息
Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France.
Université Paris-Saclay, CEA, CNRS, BAOBAB, NeuroSpin, 91191 Gif-sur-Yvette, France.
出版信息
Nanoscale. 2021 Feb 4;13(4):2373-2377. doi: 10.1039/d0nr08200g.
We describe herein the assembly and in vivo evaluation of a tailor-made micellar carrier system designed for the optimized encapsulation of a superfluorinated MRI probe and further targeting of solid tumors. The in vivo validation was carried out on MC38 tumor-bearing mice which allowed the confirmation of the efficient targeting properties of the nano-carrier, as monitored by 19F-MRI.
我们在此描述了一种量身定制的胶束载体系统的组装及其体内评估，该系统旨在优化超氟化磁共振成像（MRI）探针的封装，并进一步靶向实体瘤。体内验证是在携带MC38肿瘤的小鼠身上进行的，通过19F-MRI监测，证实了纳米载体具有有效的靶向特性。
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