Ruiz de Aguiar A, Medina Núñez J A, Lopez Domingo M I, Villacorta Patiño J, Leguey Jimenez S
Department of Medicine, San Carlos Hospital, Complutense University, Madrid, Spain.
J Hepatol. 1988 Feb;6(1):71-9. doi: 10.1016/s0168-8278(88)80464-1.
CaCO3 has been studied in twelve gallstones in which cholesterol predominated. Different polymorphs of CaCO3, as well as carbonate-apatite, were characterised by X-ray diffraction, polarised light microscopy and scanning electron microscopy. Crystals and rhombohedral aggregates of calcite, aggregates of small crystals and tabular crystals of vaterite and fibrous radial aggregates in the form of ooliths were found. In microscopic studies on sections of the stones, CaCO3 was localised mainly in the periphery in the form of layers or bands associated with calcium bilirubinate which was deposited in close relation to it. The phenomena contributing to the precipitation of CaCO3 are discussed, as is the importance of the latter in resistance to the pharmacologic treatment of gallstone disease.
对12颗以胆固醇为主的胆结石中的碳酸钙进行了研究。通过X射线衍射、偏光显微镜和扫描电子显微镜对碳酸钙的不同多晶型物以及碳酸磷灰石进行了表征。发现了方解石的晶体和菱面体聚集体、球霰石的小晶体聚集体和板状晶体以及呈鲕粒状的纤维状放射状聚集体。在对结石切片的显微镜研究中，碳酸钙主要以与胆红素钙相关的层或带的形式位于周边，胆红素钙与之紧密沉积。文中讨论了导致碳酸钙沉淀的现象，以及碳酸钙在胆结石疾病药物治疗抗性中的重要性。
