Paul W S, Cowan J, Jackson G G
Department of Medicine, University of Illinois College of Medicine, Chicago.
J Infect Dis. 1988 Apr;157(4):633-9. doi: 10.1093/infdis/157.4.633.
A prospective survey of acute respiratory illness (RI) was made among 329 vaccinated and unvaccinated ambulatory patients with high-risk factors for influenza. Surveillance for virus during the influenza season revealed the predominance of influenza A and B in sequential periods. During the influenza A period, febrile RI was greatest among patients with chronic pulmonary disease; among 66 patients, vaccination significantly reduced RI. Age greater than 65 y (199 patients) and heart (90 patients) and metabolic diseases (151 patients) did not increase the relative frequency of febrile RI, and vaccine administration caused no apparent reduction in frequency of RI. During the influenza B period, no differences in RI were observed between the groups, and the frequency of RI was unrelated to vaccination. Variability in virus and vaccine specificities may have been important. Except for one subset of specific virus and host conditions, no overall reduction in influenza-like or total RI was observed from vaccinating ambulatory, high-risk patients.
对329名有流感高危因素的已接种和未接种疫苗的门诊患者进行了急性呼吸道疾病（RI）的前瞻性调查。在流感季节对病毒进行监测发现，甲型和乙型流感在不同时期占主导地位。在甲型流感期间，慢性肺病患者中发热性RI最为常见；在66名患者中，接种疫苗显著降低了RI。65岁以上（199名患者）以及患有心脏疾病（90名患者）和代谢疾病（151名患者）的患者，发热性RI的相对频率并未增加，接种疫苗也未使RI频率明显降低。在乙型流感期间，两组之间的RI没有差异，且RI频率与接种疫苗无关。病毒和疫苗特异性的变异性可能很重要。除了特定病毒和宿主条件的一个子集外，对门诊高危患者接种疫苗并未观察到流感样或总RI的总体减少。
