晚睡与中年和老年人心绞痛有关：来自睡眠心脏健康研究的结果。

Later bedtime is associated with angina pectoris in middle-aged and older adults: results from the Sleep Heart Health Study.

机构信息

Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Department of Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

出版信息

Sleep Med. 2021 Mar;79:1-5. doi: 10.1016/j.sleep.2020.12.035. Epub 2020 Dec 31.

DOI:10.1016/j.sleep.2020.12.035

PMID:33465737

Abstract

OBJECTIVES

Sleep timing is related to several risk factors for angina pectoris (AP), such as obesity and diabetes. This study was designed to evaluate the relationship between sleep timing and AP, specifically whether later bedtime was associated with AP in middle-aged and older adults.

METHODS

This community-based study was based on the Sleep Heart Health Study cohort and included 4710 participants (45.9% men, aged 63.3 ± 11.0 years). Lifestyle and epidemiological information were obtained from baseline records. Self-reported sleep measures provided information on bedtime and wake-up time of weekdays and weekends. Individuals were divided into three categories according to bedtime (≤22:00, 22:01-23:00, and >23:00). Odds ratios (OR) and 95% confidence intervals (CIs) of AP for bedtimes were estimated with multivariate logistic regression analysis.

RESULTS

The prevalence of AP was 44.2% and the distribution of weekday bedtimes ≤22:00, 22:01-23:00 and >23:00 were 36.6%, 47.5% and 46.0%, respectively. After adjusting for potential confounders, weekday bedtimes >23:00 (OR 1.34; 95% CI 1.13-1.60; P = 0.001) and 22:01-23:00 (OR 1.54; 95% CI 1.29-1.82; P < 0.001) were significantly associated with an increased risk of AP compared with the reference group (≤22:00). In addition, weekend bedtimes >23:00 (OR 1.44; 95% CI 1.20-1.73; P < 0.001) and 22:01-23:00 (OR 1.70; 95% CI 1.40-2.05; P < 0.001) increased the risk of AP.

CONCLUSIONS

Later bedtimes on both weekdays and weekends were significantly associated with an increased prevalence of AP. Early bedtimes may help people decrease the risk of AP.

摘要

目的

睡眠时间与心绞痛（AP）的几个危险因素有关，例如肥胖和糖尿病。本研究旨在评估睡眠时间与 AP 的关系，特别是晚睡是否与中年和老年人的 AP 有关。

方法

这项基于社区的研究基于睡眠心脏健康研究队列，包括 4710 名参与者（45.9%为男性，年龄 63.3±11.0 岁）。从基线记录中获得生活方式和流行病学信息。自我报告的睡眠测量提供了工作日和周末的就寝时间和起床时间信息。根据就寝时间（≤22:00、22:01-23:00 和>23:00）将个体分为三组。使用多变量逻辑回归分析估计 AP 的 bedtime 比值比（OR）和 95%置信区间（CI）。

结果

AP 的患病率为 44.2%，工作日就寝时间≤22:00、22:01-23:00 和>23:00 的分布分别为 36.6%、47.5%和 46.0%。调整潜在混杂因素后，工作日就寝时间>23:00（OR 1.34；95%CI 1.13-1.60；P=0.001）和 22:01-23:00（OR 1.54；95%CI 1.29-1.82；P<0.001）与 AP 风险增加显著相关，与参考组（≤22:00）相比。此外，周末就寝时间>23:00（OR 1.44；95%CI 1.20-1.73；P<0.001）和 22:01-23:00（OR 1.70；95%CI 1.40-2.05；P<0.001）增加了 AP 的风险。