Department of Pathology.
Department of Otolaryngology, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
Medicine (Baltimore). 2021 Jan 15;100(2):e24011. doi: 10.1097/MD.0000000000024011.
Salivary duct carcinoma (SDC) is a rare and highly aggressive cancer with a poor prognosis. SDC demonstrates a potential for invasive growth with early regional and distant metastasis to organs, such as bone, lung, liver, and brain. Because, adrenal gland metastasis from SDC is rare, its treatment options are not well established. Herein, we report a case of SDC metastasis from the parotid gland to the adrenal gland, which was successfully treated by surgery.
The patient had an abnormal but painless lump on the right parotid gland. The size of the mass had increased over a period of 3 years. The patient underwent complete removal of the right parotid gland and radical neck dissection followed by adjuvant radiotherapy and chemotherapy. Two years later, a mass was identified in the left adrenal gland by computed tomography. As no local recurrence or metastasis to other organs was observed, the patient underwent adrenalectomy.
Metastasis of SDC in the adrenal gland was confirmed by histopathological examination of the adrenalectomized specimen.
After adrenalectomy, the patient was followed-up without adjuvant therapy.
The patient was well and alive during the 13-month postoperative follow-up period without any complications.
Surgical resection of solitary metastatic lesion may show a survival benefit with metastatic SDC.
唾液腺癌（SDC）是一种罕见且高度侵袭性的癌症，预后不良。SDC 具有侵袭性生长的潜力，早期会发生局部和远处转移，转移至骨骼、肺、肝和脑等器官。由于 SDC 向肾上腺转移较为罕见，其治疗方案尚未明确。本文报道了一例 SDC 从腮腺转移至肾上腺，经手术成功治疗的病例。
患者右侧腮腺有一异常但无痛性肿块，肿块大小在 3 年内逐渐增大。患者接受了右侧腮腺全切除和根治性颈清扫术，随后接受了辅助放疗和化疗。2 年后，CT 检查发现左侧肾上腺有一肿块。由于未观察到局部复发或其他器官转移，患者接受了肾上腺切除术。
肾上腺切除标本的组织病理学检查证实了 SDC 的肾上腺转移。
肾上腺切除术后，患者未接受辅助治疗，仅进行随访。
患者术后 13 个月随访期间情况良好，无任何并发症，存活至今。
对于转移性 SDC 的孤立性转移病灶，手术切除可能具有生存获益。
