硅酸钠复合物对蛇毒诱导的出血活性的影响。
Effects of Sodium Silicate Complex against Hemorrhagic Activities Induced by Venom.
机构信息
Emergency Department, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Department of Emergency Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
出版信息
Toxins (Basel). 2021 Jan 14;13(1):59. doi: 10.3390/toxins13010059.
poses a serious medical threat to humans in Southern and Southeastern Asia. Hemorrhage is one of the conspicuous toxicities related to the pathology of envenoming. Previous in vitro and in vivo studies showed that a silica-derived reagent, sodium silicate complex (SSC), was able to neutralize hemorrhagic and proteolytic activities induced by pit viper venoms, including , and . In this study, we validated that SSC could neutralize enzymatic and toxic effects caused by the venom of . We found that SSC inhibited the hemolytic and proteolytic activities induced by venom in vitro. In addition, we demonstrated that SSC could block intradermal hemorrhage caused by venom in a mouse model. Finally, SSC could neutralize lethal effects of venom in the mice. Therefore, SSC is a candidate for further development as a potential onsite first-aid treatment for envenoming.
在南亚和东南亚对人类构成严重的医学威胁。出血是与蛇毒中毒病理相关的明显毒性之一。先前的体外和体内研究表明，一种源自二氧化硅的试剂，硅酸钠复合物（SSC），能够中和包括 、 和 在内的蝰蛇毒液引起的出血性和蛋白水解活性。在这项研究中，我们验证了 SSC 可以中和 毒液引起的酶和毒性作用。我们发现 SSC 可以抑制 毒液在体外引起的溶血和蛋白水解活性。此外，我们证明 SSC 可以阻止 毒液在小鼠模型中引起的皮内出血。最后，SSC 可以中和 毒液对小鼠的致死作用。因此，SSC 是进一步开发作为蛇伤现场急救治疗的候选药物。
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