Goodwin D A, Meares C F, McCall M J, McTigue M, Chaovapong W
Nuclear Medicine Service, Veterans Administration Medical Center, Palo Alto, CA 94304.
J Nucl Med. 1988 Feb;29(2):226-34.
A method of tumor imaging utilizing the nonspecific accumulation of antibody through leaky capillaries is described, in which the antibody and the radiolabel are administered separately. Nonradioactive antibody is given first (pre-targeted), and allowed adequate time to reach maximum tumor concentration. Depending on the antibody, this may take several days. At the time of maximum tumor concentration of nonradioactive antibody, the blood is quickly cleared of excess circulating nonradioactive antibody using a special i.v. "chase". The radiolabel then is given and imaging done in 1 to 3 hr. The use of short lived tracers (hours) to image antibodies that localize slowly (days) in-vivo is made possible by this method.
描述了一种利用抗体通过渗漏毛细血管的非特异性聚集进行肿瘤成像的方法，其中抗体和放射性标记物分别给药。首先给予非放射性抗体（预靶向），并给予足够时间以达到最大肿瘤浓度。根据抗体的不同，这可能需要几天时间。在非放射性抗体达到最大肿瘤浓度时，使用特殊的静脉“追踪”快速清除血液中多余的循环非放射性抗体。然后给予放射性标记物，并在1至3小时内进行成像。通过这种方法，可以使用短寿命示踪剂（数小时）对在体内缓慢定位（数天）的抗体进行成像。
