Kristensen Morten Tange, Hulsbæk Signe, Faber Louise Lohmann, Kronborg Lise
Physical Medicine and Rehabilitation Research-Copenhagen (PMR-C), Departments of Physical Therapy and Orthopedic Surgery, Amager-Hvidovre Hospital, University of Copenhagen, 2650 Hvidovre, Denmark.
Institute of Clinical Medicine, University of Copenhagen, Nørrebro, 2200 Copenhagen, Denmark.
Geriatrics (Basel). 2021 Jan 15;6(1):8. doi: 10.3390/geriatrics6010008.
To examine if knee-extension strength (KES) measures indicating probable sarcopenia are associated with health-related outcomes and if KES and hand grip strength (HGS) measures are associated with 1-year mortality after hip fracture. Two groups of older patients with hip fracture had either HGS ( = 32) or KES ( = 150) assessed during their acute hospital stay. Cut-points for HGS (<27 kg for men and <16 kg for women), and cut-points for maximal isometric KES (non-fractured limb), being the lowest sex-specific quintile (<23.64 kg for men and <15.24 kg for women), were used to examine association with health-related outcomes and 1-year mortality. Overall, 1-year mortality was 12.6% in the two strength groups, of which 47% (HGS) and 46% (KES) respectively, were classified as probable sarcopenia. Probable sarcopenia patients (KES) had lower prefracture function, performed poorly in mobility measures and expressed a greater concern of falling compared to their stronger counterparts. Hazard ratio for 1-year mortality was 2.7 (95%CI = 0.49-14.7, = 0.3) for HGS and 9.8 (95%CI = 2.2-43.0, = 0.002) for KES for probable sarcopenia patients compared to those not. Sex-specific KES measures indicating sarcopenia is associated with health-related outcomes and a strong predictor of 1-year mortality after hip fracture.
为了研究表明可能存在肌肉减少症的膝关节伸展力量(KES)测量指标是否与健康相关结局相关,以及KES和握力(HGS)测量指标是否与髋部骨折后的1年死亡率相关。两组老年髋部骨折患者在急性住院期间接受了HGS(n = 32)或KES(n = 150)评估。使用HGS的切点(男性<27 kg,女性<16 kg)以及最大等长KES(非骨折肢体)的切点,即性别特异性最低五分位数(男性<23.64 kg,女性<15.24 kg),来检验与健康相关结局和1年死亡率的关联。总体而言,两个力量组的1年死亡率为12.6%,其中分别有47%(HGS)和46%(KES)被归类为可能存在肌肉减少症。与较强的同龄人相比,可能存在肌肉减少症的患者(KES)骨折前功能较低,在 mobility 测量中表现较差,并且对跌倒的担忧更大。与未患可能存在肌肉减少症的患者相比,可能存在肌肉减少症的患者中,HGS的1年死亡率风险比为2.7(95%CI = 0.49 - 14.7,P = 0.3),KES为9.8(95%CI = 2.2 - 43.0,P = 0.002)。表明存在肌肉减少症的性别特异性KES测量指标与健康相关结局相关,并且是髋部骨折后1年死亡率的有力预测指标。 (注:原文中“mobility measures”未明确中文释义,保留英文)