Department of Nephrology, the First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China.
953th Hospital, Shigatse Branch, Xinqiao Hospital, Army Medical University (Third Military Medical University), Shigatse 857000, China.
Exp Biol Med (Maywood). 2021 Apr;246(8):986-995. doi: 10.1177/1535370220981756. Epub 2021 Jan 19.
Acute kidney injury is a serious health hazard disease due to its complex etiology and lack of effective treatments, resulting in high medical costs and high mortality. At present, a large number of basic research studies on acute kidney injury have been carried out. However, acute kidney injury models established in rodents sometimes do not simulate the course of human disease well. Research in large animal models of acute kidney injury is relatively rare, and methods to build a mature model of acute kidney injury have failed. Because its kidney anatomy and morphology are very similar to those in humans, the mini pig is an ideal animal in which to model kidney disease. Nephrotoxic drug-induced acute kidney injury has a high incidence. In this study, we established models of acute kidney injury induced by two drugs (gentamicin and cisplatin). Finally, the model of cisplatin-induced acute kidney injury was developed successfully, but we found the model of gentamycin-induced acute kidney injury was not reproducible. Compared to other models, these models better represent acute kidney injury caused by antibiotics and chemotherapeutic drugs and provide a basis for the study of new treatments for acute kidney injury in a large animal model.
急性肾损伤是一种严重的健康危害疾病，由于其病因复杂且缺乏有效治疗方法，导致医疗费用高、死亡率高。目前，已经进行了大量关于急性肾损伤的基础研究。然而，啮齿动物模型建立的急性肾损伤有时并不能很好地模拟人类疾病的过程。大型动物急性肾损伤模型的研究相对较少，而且建立成熟的急性肾损伤模型的方法也失败了。由于迷你猪的肾脏解剖结构和形态与人类非常相似，因此它是一种理想的肾脏疾病模型动物。肾毒性药物诱导的急性肾损伤发病率较高。在本研究中，我们建立了两种药物（庆大霉素和顺铂）诱导的急性肾损伤模型。最后，成功建立了顺铂诱导的急性肾损伤模型，但我们发现庆大霉素诱导的急性肾损伤模型不可重现。与其他模型相比，这些模型更好地代表了抗生素和化疗药物引起的急性肾损伤，为在大型动物模型中研究急性肾损伤的新治疗方法提供了依据。
