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Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.

作者信息

Jackson W P, Islip P J, Kneen G, Pugh A, Wates P J

机构信息

Wellcome Research Laboratories, Beckenham, Kent, United Kingdom.

出版信息

J Med Chem. 1988 Mar;31(3):499-500. doi: 10.1021/jm00398a001.

DOI:10.1021/jm00398a001
PMID:3346867
Abstract
摘要

相似文献

1
Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.乙酰氧肟酸作为强效、选择性、口服活性的5-脂氧合酶抑制剂。
J Med Chem. 1988 Mar;31(3):499-500. doi: 10.1021/jm00398a001.
2
The effects of a novel series of selective inhibitors of arachidonate 5-lipoxygenase on anaphylactic and inflammatory responses.新型花生四烯酸5-脂氧合酶选择性抑制剂系列对过敏和炎症反应的影响。
Ann N Y Acad Sci. 1988;524:307-20. doi: 10.1111/j.1749-6632.1988.tb38554.x.
3
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo.新型乙酰氧肟酸对花生四烯酸5-脂氧合酶的选择性抑制：体外和体内生化评估
Br J Pharmacol. 1988 Jun;94(2):528-39. doi: 10.1111/j.1476-5381.1988.tb11557.x.
4
In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase.5-脂氧合酶异羟肟酸抑制剂的体内特性研究
J Med Chem. 1987 Nov;30(11):2121-6. doi: 10.1021/jm00394a032.
5
Hydroxamic acid inhibitors of 5-lipoxygenase.5-脂氧合酶的异羟肟酸抑制剂
J Med Chem. 1987 Mar;30(3):574-80. doi: 10.1021/jm00386a022.
6
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on bronchial anaphylaxis in anaesthetized guinea-pigs.新型乙酰氧肟酸对花生四烯酸5-脂氧合酶的选择性抑制作用：对麻醉豚鼠支气管过敏反应的影响。
Br J Pharmacol. 1988 Jun;94(2):540-6. doi: 10.1111/j.1476-5381.1988.tb11558.x.
7
Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.非甾体抗炎药异羟肟酸。环氧化酶和5-脂氧合酶的双重抑制剂。
J Med Chem. 1990 Aug;33(8):2070-2. doi: 10.1021/jm00170a004.
8
Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships.5-脂氧合酶的异羟肟酸抑制剂：定量构效关系
J Med Chem. 1990 Mar;33(3):992-8. doi: 10.1021/jm00165a017.
9
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on acute inflammatory responses.新型乙酰氧肟酸对花生四烯酸5-脂氧合酶的选择性抑制作用：对急性炎症反应的影响
Br J Pharmacol. 1988 Jun;94(2):547-51. doi: 10.1111/j.1476-5381.1988.tb11559.x.
10
Failure of the inhibition of rat gastric mucosal 5-lipoxygenase by novel acetohydroxamic acids to prevent ethanol-induced damage.新型乙酰氧肟酸对大鼠胃黏膜5-脂氧合酶抑制作用未能预防乙醇诱导的损伤。
Br J Pharmacol. 1988 Sep;95(1):155-62. doi: 10.1111/j.1476-5381.1988.tb16559.x.

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BMD188, A novel hydroxamic acid compound, demonstrates potent anti-prostate cancer effects in vitro and in vivo by inducing apoptosis: requirements for mitochondria, reactive oxygen species, and proteases.BMD188是一种新型异羟肟酸化合物，通过诱导细胞凋亡在体外和体内均表现出强大的抗前列腺癌作用：对线粒体、活性氧和蛋白酶的需求。
Pathol Oncol Res. 1998;4(3):179-90. doi: 10.1007/BF02905247.
2
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on bronchial anaphylaxis in anaesthetized guinea-pigs.新型乙酰氧肟酸对花生四烯酸5-脂氧合酶的选择性抑制作用：对麻醉豚鼠支气管过敏反应的影响。
Br J Pharmacol. 1988 Jun;94(2):540-6. doi: 10.1111/j.1476-5381.1988.tb11558.x.
3
Failure of the inhibition of rat gastric mucosal 5-lipoxygenase by novel acetohydroxamic acids to prevent ethanol-induced damage.
新型乙酰氧肟酸对大鼠胃黏膜5-脂氧合酶抑制作用未能预防乙醇诱导的损伤。
Br J Pharmacol. 1988 Sep;95(1):155-62. doi: 10.1111/j.1476-5381.1988.tb16559.x.
4
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on acute inflammatory responses.新型乙酰氧肟酸对花生四烯酸5-脂氧合酶的选择性抑制作用：对急性炎症反应的影响
Br J Pharmacol. 1988 Jun;94(2):547-51. doi: 10.1111/j.1476-5381.1988.tb11559.x.
5
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo.新型乙酰氧肟酸对花生四烯酸5-脂氧合酶的选择性抑制：体外和体内生化评估
Br J Pharmacol. 1988 Jun;94(2):528-39. doi: 10.1111/j.1476-5381.1988.tb11557.x.
6
The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C.前列腺素TP和DP受体在麻醉豚鼠吸入PGD2所致支气管收缩效应中的作用：DP拮抗剂BW A868C的影响
Br J Pharmacol. 1990 Aug;100(4):761-6. doi: 10.1111/j.1476-5381.1990.tb14089.x.
7
Pseudoperoxidase activity of 5-lipoxygenase stimulated by potent benzofuranol and N-hydroxyurea inhibitors of the lipoxygenase reaction.脂氧合酶反应的强效苯并呋喃醇和N-羟基脲抑制剂刺激5-脂氧合酶的假过氧化物酶活性。
Biochem J. 1991 Feb 15;274 ( Pt 1)(Pt 1):287-92. doi: 10.1042/bj2740287.