Makino Yoshinari, Kawamata Ayumi, Hikino Hajime, Murata Yoko, Takahashi Takuya, Miura Hiroshi
Dept. of Breast Surgery, Matsue Red Cross Hospital.
Gan To Kagaku Ryoho. 2020 Dec;47(13):1945-1947.
Acinic cell carcinoma(ACC)is an invasive malignancy primarily characterized by proliferation of tumor cells that resemble acinar cells of the salivary glands and pancreas. ACC of the mammary glands is rare. We report a case of primary ACC of the breast. Two masses were revealed in the left mammary gland of a 57-year-old woman who visited our hospital through screening mammography. The lesions were identified as synchronous multiple breast carcinoma of 2 different histological types; ACC and tubulolobular carcinoma. For treatment, left mastectomy and sentinel lymph node biopsy were performed, followed by postoperative chemotherapy and endocrine therapy. Hematoxylin-eosin staining of ACC revealed abundant acinar- like structures formed by tumor cells with prominent eosinophilic granules in the cytoplasm. Immunostaining was positive for S-100 protein, α1-antichymotrypsin, α1-antitrypsin, and lysozyme. The tumor cells were negative for estrogen, progesterone, and HER2 receptors, which indicated that they had a triple-negative phenotype. Although primary ACC of the breast is regarded as low-grade triple-negative breast carcinoma with a favorable prognosis, further accumulation of cases may be needed to elucidate the biological features of ACC and investigate appropriate therapeutic strategies.
腺泡细胞癌（ACC）是一种侵袭性恶性肿瘤，主要特征是肿瘤细胞增殖，这些细胞类似于唾液腺和胰腺的腺泡细胞。乳腺的ACC很罕见。我们报告一例乳腺原发性ACC。一名57岁女性通过乳腺钼靶筛查就诊于我院，其左乳发现两个肿块。这些病变被确定为两种不同组织学类型的同步性多原发性乳腺癌；ACC和小管小叶癌。治疗方面，进行了左乳切除术和前哨淋巴结活检，随后进行术后化疗和内分泌治疗。ACC的苏木精-伊红染色显示肿瘤细胞形成丰富的腺泡样结构，细胞质中有明显的嗜酸性颗粒。免疫染色显示S-100蛋白、α1-抗糜蛋白酶、α1-抗胰蛋白酶和溶菌酶呈阳性。肿瘤细胞雌激素、孕激素和HER2受体均为阴性，表明它们具有三阴性表型。尽管乳腺原发性ACC被认为是预后良好的低级别三阴性乳腺癌，但可能需要进一步积累病例以阐明ACC的生物学特征并研究合适的治疗策略。
