Li Hongmei, Wang Fuzhi, Shen Pingrong, Zhou Feng
Department of Pathology Department of Obstetrics and Gynecology, Ninghai Maternity and Child Care Hospital, Ninghai Department of Pathology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Medicine (Baltimore). 2017 Nov;96(47):e8866. doi: 10.1097/MD.0000000000008866.
Acinic cell carcinoma (AcCC) of the breast is a rare histological type of malignant epithelial neoplasm exhibiting acinic cell differentiation.
A 52-year-old woman presented to the hospital with a palpable mass over the upper outer quadrant of the right breast.
Physical examination revealed an irregular mass in the lateral upper quadrant of the left breast, approximately 1.5 cm in diameter. Histologically, the tumor cells were round to oval, had displaced nuclei with striking single nucleoli and basophilic cytoplasm, and contained large coarse cytoplasmic granules. They showed an infiltrating growth pattern with a combination of cystic and cribriform feature. We diagnosed the tumor as AcCC of the breast.
The patient was given a simple mastectomy and sentinel lymph node biopsy. After the surgery, AcCC of the breast was confirmed histologically.
The patient was symptom free 3 months after surgery.
AcCC of the breast is a very rare tumor, and its prognosis appears to be good. Thus, treatment followed the guidelines for invasive breast carcinoma and no further therapy was suggested by oncologists based on the tumor biology.
乳腺腺泡细胞癌（AcCC）是一种罕见的恶性上皮性肿瘤组织学类型，表现为腺泡细胞分化。
一名52岁女性因右乳外上象限可触及肿块入院。
体格检查发现左乳外上象限有一不规则肿块，直径约1.5厘米。组织学上，肿瘤细胞呈圆形至椭圆形，核移位，有明显的单个核仁及嗜碱性细胞质，且含有粗大的胞质颗粒。它们呈浸润性生长模式，伴有囊性和筛状特征。我们将该肿瘤诊断为乳腺腺泡细胞癌。
患者接受了单纯乳房切除术和前哨淋巴结活检。术后，经组织学证实为乳腺腺泡细胞癌。
患者术后3个月无症状。
乳腺腺泡细胞癌是一种非常罕见的肿瘤，其预后似乎良好。因此，治疗遵循浸润性乳腺癌的指南，肿瘤学家基于肿瘤生物学未建议进一步治疗。
