Ochi Fumiaki, Miyoshi Takayuki, Nishida Maiko, Watanabe Nobuyuki, Ujiie Kazuto, Nakamura Yoshitaka, Ito Norio, Takemura Manabu, Yamaguchi Akihiro, Kakihara Naoki, Ikawa Osamu, Okano Shinji, Taniguchi Hiroki
Dept. of Surgery, Japanese Red Cross Kyoto Daini Hospital.
Gan To Kagaku Ryoho. 2020 Dec;47(13):2355-2357.
Gastric adenocarcinoma with enteroblastic differentiation(GAED)is a rare disease that is classified as a special type in the 15th edition Japanese Classification of Gastric Carcinoma. GAED is considered to have a poor prognosis. We report about a 76-year-old man with GAED who presented with complaints of poor appetite and weight loss. He was suspected of having gastric cancer based on ultrasonography and computed tomography findings and was referred to our hospital by his home doctor. Upper gastrointestinal endoscopy revealed a gastric cancer in the lesser curvature of the gastric antrum. Distal gastrectomy was performed. Histopathology showed a moderately differentiated adenocarcinoma with a clear cytoplasm. Immunostaining was positive for Sal-like protein 4(SALL4)and negative for α-fetoprotein(AFP). The patient was diagnosed as having GAED. Vascular and lymphatic invasion were not observed. He was discharged on the 9th day after surgery. At 5 months postoperatively, he was treated with adjuvant chemotherapy, and no recurrence was noted. GAED is a rare disease with a poor prognosis. We report this case and discuss relevant literature.
具有成肠细胞分化的胃腺癌（GAED）是一种罕见疾病，在第15版日本胃癌分类中被归类为特殊类型。GAED被认为预后较差。我们报告一例76岁患有GAED的男性患者，其主诉为食欲减退和体重减轻。根据超声和计算机断层扫描结果，他被怀疑患有胃癌，并由家庭医生转诊至我院。上消化道内镜检查显示胃窦小弯处有胃癌。遂行远端胃切除术。组织病理学显示为中等分化腺癌，细胞质清晰。免疫染色显示Sal样蛋白4（SALL4）呈阳性，甲胎蛋白（AFP）呈阴性。该患者被诊断为GAED。未观察到血管和淋巴浸润。他在术后第9天出院。术后5个月，他接受了辅助化疗，未发现复发。GAED是一种预后较差的罕见疾病。我们报告该病例并讨论相关文献。
