肝切除术后结直肠癌肝转移患者中，[具体指标1]、[具体指标2]和[具体指标3]对早期复发的预后意义
Prognostic Significance of , and for Early Recurrence in Patients with Colorectal Liver Metastasis After Liver Resection.
作者信息
Bogdanovic Aleksandar, Despotovic Jovana, Galun Danijel, Bidzic Nemanja, Nikolic Aleksandra, Rosic Jovana, Krivokapic Zoran
机构信息
HPB Unit, Clinic for Digestive Surgery, Clinical Center of Serbia, Belgrade, 11 000, Serbia.
School of Medicine, University of Belgrade, Belgrade 11 000, Serbia.
出版信息
Cancer Manag Res. 2021 Jan 11;13:163-171. doi: 10.2147/CMAR.S287974. eCollection 2021.
PURPOSE
There are limited data on expression of epithelial-mesenchymal transition (EMT) markers in patients with colorectal liver metastases (CRLM). The study aim was to evaluate the expression and prognostic significance of E-cadherin (), fibronectin () and vimentin () in patients with CRLM after curative-intent liver resection.
PATIENTS AND METHODS
Thirty patients with CRLM managed by curative-intent liver resection were included in this prospective pilot study. Blood samples, colorectal liver metastases and surrounding non-tumor liver tissue were collected. Expression of , and was analyzed by quantitative real-time polymerase chain reaction. Expression in CRLM and non-tumor liver tissue was compared, while expression in serum was correlated with CRLM expression. One-year recurrence-free survival was compared between patients with low and high , and expression.
RESULTS
The expression of was similar in CRLM and non-tumor liver tissues, while and expression was significantly lower in metastatic tissue (=0.003 and <0.001, respectively). Serum expression of and was detected in 66.7% and 93.3% of patients, respectively, while was not detected in any of the patients. The correlation of and expression between CRLM and serum was not statistically significant. Decreased expression in CRLM and decreased expression in serum were associated with early recurrence after surgical treatment of CRLM.
CONCLUSION
Lower expression of in CRLM and lower serum expression of were found to be associated with early recurrence after liver resection for CRLM.
目的
关于结直肠癌肝转移（CRLM）患者上皮-间质转化（EMT）标志物表达的数据有限。本研究旨在评估E-钙黏蛋白（E-cadherin）、纤连蛋白（fibronectin）和波形蛋白（vimentin）在接受根治性肝切除的CRLM患者中的表达及预后意义。
患者与方法
本前瞻性初步研究纳入了30例接受根治性肝切除治疗的CRLM患者。采集血样、结直肠癌肝转移灶及周围非肿瘤性肝组织。通过定量实时聚合酶链反应分析E-cadherin、fibronectin和vimentin的表达。比较CRLM和非肿瘤性肝组织中的表达情况，同时分析血清中的表达与CRLM表达的相关性。比较E-cadherin、fibronectin和vimentin低表达与高表达患者的1年无复发生存率。
结果
CRLM和非肿瘤性肝组织中E-cadherin的表达相似，而转移组织中fibronectin和vimentin的表达显著降低（分别为P = 0.003和P < 0.001）。分别在66.7%和93.3%的患者血清中检测到fibronectin和vimentin的表达，而所有患者血清中均未检测到E-cadherin的表达。CRLM与血清中fibronectin和vimentin表达的相关性无统计学意义。CRLM中E-cadherin表达降低及血清中fibronectin表达降低与CRLM手术治疗后的早期复发相关。
结论
发现CRLM中E-cadherin表达降低及血清中fibronectin表达降低与CRLM肝切除术后的早期复发相关。
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