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当前时代的白喉:普遍接种疫苗。

Diphtheria in the current era of universal vaccination.

机构信息

Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India, Email:

Department of Internal Medicine, PGIMER, Chandigarh, India.

出版信息

J R Coll Physicians Edinb. 2020 Dec;50(4):408-410. doi: 10.4997/JRCPE.2020.412.

Abstract

Diphtheria is a vaccination preventable infectious disease with local and systemic complications predominantly affecting upper respiratory tract in younger (<5-year age) children. Its virulence is due to its ability to produce toxin which can cause fatal complications such as myocarditis and permanent damage in form of peripheral neuropathy. Diagnosis of diphtheria is primarily clinical supported by demonstration of toxin producing bacteria by culture. Early diagnosis and management with diphtheria anti-toxin can prevent mortality and morbidity. Here we present a case of 16-year-old boy managed with azithromycin, amoxycillin-clavulanic acid and diphtheria anti-toxin with complete recovery.This case brings out the importance of recognising the re-emergence of diphtheria in older age groups. Lacunae in the universal immunisation process, rumours on vaccination effects and poor living conditions for refugee population are likely reasons in Asia and Europe. Universal immunisation, early diagnosis, prophylaxis and adequate supportive care are measures to prevent it.

摘要

白喉是一种可通过疫苗预防的传染病,主要影响 5 岁以下儿童的上呼吸道,可引起局部和全身并发症。其毒性是由于能够产生毒素,从而导致致命的并发症,如心肌炎和外周神经病变等永久性损害。白喉的诊断主要依靠临床诊断,并通过培养来证实产毒细菌的存在。早期使用白喉抗毒素诊断和治疗可以预防死亡率和发病率。在这里,我们报告了一例 16 岁男孩的病例,他接受了阿奇霉素、阿莫西林克拉维酸和白喉抗毒素治疗,最终完全康复。这个病例表明,需要认识到白喉在年龄较大的人群中的再次出现。亚洲和欧洲普遍存在免疫接种过程中的空白、关于疫苗效果的谣言以及难民人口的恶劣生活条件,可能是导致这种情况的原因。普遍免疫接种、早期诊断、预防和适当的支持性护理是预防白喉的措施。

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