第二代移民和瑞典本地人的骨质疏松性骨折。
Osteoporotic fractures in second-generation immigrants and Swedish natives.
机构信息
Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Alfred Nobels Allé 23, SE-141 83, Huddinge, Sweden.
Center for Primary Health Care Research, Lund University, Malmö, Sweden.
出版信息
Osteoporos Int. 2021 Jul;32(7):1343-1350. doi: 10.1007/s00198-020-05776-4. Epub 2021 Jan 19.
UNLABELLED
In this national study of osteoporotic fractures in second-generation immigrants in Sweden, we found a similar risk of osteoporotic fractures in general compared to Swedish natives, which suggests that environmental factors are important for the high risk of osteoporotic fractures in Nordic countries.
INTRODUCTION
Second generation immigrants may have a similar environment as individuals with two native-born parents. These individuals may be of interest to study concerning whether environmental or hereditary factors could be mostly associated to the risk of osteoporotic fractures. The aim of this study was to analyse the risk of osteoporotic fractures in second-generation immigrants compared to Swedish natives.
METHODS
This was a nationwide study of individuals aged 50 years of age and older (N = 1,377,035; 691,750 men and 685,285 women). Osteoporotic fractures were defined as at least one registered diagnosis of fractures in the hip, humerus, forearm or vertebrae, in the National Patient Register between January 1, 1998, and December 31, 2012. Cox regression analysis was used to estimate the relative risk (hazard ratios (HR) with 95% confidence intervals (CI)) of incident osteoporotic fractures in second generation immigrants compared to Swedish natives. The Cox regression models were adjusted for age, comorbidities and for sociodemographic status.
RESULTS
A total of 114,505 osteoporotic fractures were registered, 109,622 (8.4%) were among individuals with Swedish-born parents and 4883 (7.5%) among those with foreign-born parents, with distal forearm fractures dominating in general (44.9%). Fully adjusted HRs (95% CI) were for all immigrants 0.95 (95% CI, 0.91-0.99), for men 0.96 (95% CI, 0.89-1.04) and for women 0.95 (95% CI, 0.90-1.00).
CONCLUSIONS
We observed a similar risk of osteoporotic fractures among second-generation immigrants as in Swedish natives, which suggests that environmental factors are important for osteoporotic fractures.
目的
在这项针对瑞典骨质疏松性骨折的第二代移民的全国性研究中，我们发现一般来说，与瑞典本地人相比，骨折风险相似，这表明环境因素对于北欧国家骨质疏松性骨折的高风险很重要。
方法
这是一项针对年龄在 50 岁及以上的个体（N=1377035；691750 名男性和 685285 名女性）的全国性研究。骨质疏松性骨折的定义是至少有一次在髋部、肱骨、前臂或椎体的骨折记录，这些记录是在国家患者登记处 1998 年 1 月 1 日至 2012 年 12 月 31 日期间登记的。使用 Cox 回归分析来估计第二代移民与瑞典本地人相比，发生骨质疏松性骨折的相对风险（风险比（HR）及其 95%置信区间（CI））。Cox 回归模型调整了年龄、合并症和社会人口统计学状况。
结果
共登记了 114505 例骨质疏松性骨折，其中 109622 例（8.4%）发生在瑞典出生的父母中，4883 例（7.5%）发生在外国出生的父母中，一般来说，远端前臂骨折占主导地位（44.9%）。完全调整后的 HR（95%CI）为所有移民 0.95（95%CI，0.91-0.99），男性 0.96（95%CI，0.89-1.04）和女性 0.95（95%CI，0.90-1.00）。
结论
我们观察到第二代移民与瑞典本地人发生骨质疏松性骨折的风险相似，这表明环境因素对于骨质疏松性骨折很重要。
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