Eom Youngsub, Hyon Joon Young, Lee Hyung Keun, Song Jong Suk, Kim Hyo Myung
Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea.
Department of Ophthalmology, Korea University Ansan Hospital, Gyeonggi-do, Republic of Korea.
Jpn J Ophthalmol. 2021 Mar;65(2):261-270. doi: 10.1007/s10384-020-00803-7. Epub 2021 Jan 19.
To compare the proportions of patients satisfying Korean dry eye guidelines and Asia Dry Eye Society (ADES) diagnostic criteria and to describe the clinical characteristics and practice patterns of dry eye patients in Korea.
Prospective observational study.
This study enrolled 160 patients, with 158 patients analyzed. ADES guidelines were applied to dry eye patients satisfying the Korean dry eye guidelines. Risk factors for dry eye (e.g. visual display terminal [VDT] use) were evaluated. Dry eye subtypes were categorized as aqueous-deficient or evaporative. Objective signs (e.g. corneal and keratoconjunctival staining scores, tear break-up time [TBUT], and Schirmer test) and symptoms (Dry Eye-Related Quality of Life Score [DEQS] and Ocular Surface Disease Index [OSDI] questionnaire) were evaluated. Treatment patterns were also recorded.
Patients (mean age 43.1 years) were mainly women (85.4%), with a high proportion (77.2%) of VDT users. Concordance between Korean and ADES guidelines was high (94.3%), with most patients (94.3%) having tear film instability (TBUT ≤ 5 s). Evaporative dry eye occurred in 60.1% and aqueous-deficient in 39.9% of cases. Objective signs were significantly better in evaporative than in aqueous-deficient dry eye. The DEQS bothersome ocular symptoms' score was significantly higher in VDT users than in non-users. OSDI symptom severity and DEQS were significantly correlated (p < 0.001). The most common treatments were hyaluronic acid (33.5%) and diquafosol (15.2%), the latter used mainly for mild and evaporative dry eye.
The study showed high concordance between Korean and ADES diagnostic guidelines, with most patients having tear film instability.
比较符合韩国干眼指南和亚洲干眼协会（ADES）诊断标准的患者比例，并描述韩国干眼患者的临床特征和诊疗模式。
前瞻性观察性研究。
本研究纳入160例患者，对其中158例进行分析。将ADES指南应用于符合韩国干眼指南的干眼患者。评估干眼的危险因素（如使用视觉显示终端[VDT]）。干眼亚型分为水液缺乏型或蒸发过强型。评估客观体征（如角膜和角结膜染色评分、泪膜破裂时间[TBUT]和泪液分泌试验）和症状（干眼相关生活质量评分[DEQS]和眼表疾病指数[OSDI]问卷）。还记录了治疗模式。
患者（平均年龄43.1岁）主要为女性（85.4%），VDT使用者比例较高（77.2%）。韩国和ADES指南之间的一致性较高（94.3%），大多数患者（94.3%）存在泪膜不稳定（TBUT≤5秒）。蒸发过强型干眼占60.1%，水液缺乏型占39.9%。蒸发过强型干眼的客观体征明显优于水液缺乏型干眼。VDT使用者的DEQS烦扰性眼部症状评分显著高于非使用者。OSDI症状严重程度与DEQS显著相关（p<0.001）。最常用的治疗方法是透明质酸（33.5%）和地夸磷索（15.2%），后者主要用于轻度和蒸发过强型干眼。
该研究表明韩国和ADES诊断指南之间具有较高的一致性，大多数患者存在泪膜不稳定。
