实施呼吸护理措施方案和优化潜在肺供体机械通气对其的影响。
Impact of implementing a protocol of respiratory care measures and optimization of mechanical ventilation in potential lung donors.
机构信息
Hospital General de Agudos D. F. Santojanni - Buenos Aires, Argentina.
Instituto de Trasplante de la Ciudad de Buenos Aires - Buenos Aires, Argentina.
出版信息
Rev Bras Ter Intensiva. 2020 Oct-Dec;32(4):571-577. doi: 10.5935/0103-507X.20200095.
OBJECTIVE
To describe the results from the implementation of a respiratory care and mechanical ventilation protocol on potential lung donors who met the conditions for procurement. The secondary objective is to compare the results with historical data.
METHODS
This was a retrospective, observational study. It included potential donors suitable for procurement of organs who had brain death and were hospitalized in critical care units of the Autonomous City of Buenos Aires from April 2017 to March 2018. Main variables: number of potential lung donors that reached the objective of procurement, rate of lungs procured, and rate of implanted lungs. Values of p < 0.05 were considered significant.
RESULTS
Thirty potential lung donors were included, and 23 (88.5%; 95%CI 69.8 - 97.6) met the oxygenation objective. Twenty potential lung donors donated organs, of whom eight donated lungs, with which four double lung transplants and eight single lung transplants were performed. Seven of 12 lungs were procured and implanted in the preprotocol period, while all 12 were under the protocol (p = 0.38). The implantation rate was 58.3% (7/12) in the historical control period and 100% (12/12) (p = 0.04) in the study period.
目的
描述为符合获取条件的潜在肺供体实施呼吸治疗和机械通气方案的结果。次要目标是将结果与历史数据进行比较。
方法
这是一项回顾性、观察性研究。纳入 2017 年 4 月至 2018 年 3 月期间在布宜诺斯艾利斯自治市重症监护病房因脑死亡而住院的潜在器官供体，这些供体适合进行器官获取。主要变量：达到获取目标的潜在肺供体数量、获取肺的比例以及植入肺的比例。p<0.05 被认为具有统计学意义。
结果
共纳入 30 名潜在肺供体，其中 23 名（88.5%；95%CI 69.8-97.6）达到了氧合目标。20 名潜在肺供体捐献了器官，其中 8 名捐献了肺，其中 4 例进行了双肺移植，8 例进行了单肺移植。在预方案期有 7 个肺被获取并植入，而在方案期有 12 个肺都被获取并植入（p=0.38）。在历史对照期，植入率为 58.3%（7/12），而在研究期为 100%（12/12）（p=0.04）。
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