Vella F
Hemoglobin. 1977;1(7):619-50. doi: 10.3109/03630267708999171.
The structure, properties and function of, and some biosynthetic and genetic aspects of, Hb A2 are described. The structural variants of Hb A2 are reviewed and their geographical distribution presented. Hb A2, Hb A2-Flatbush and Hb A2-Babinga are characteristic of negro populations and may have originated in Western or Central Africa. Hb A2-Sphakia is characteristic of Canadian Amerindian and Hb A2-Indonesia of Indonesian/Malay populations. Hb A2-NYU has only been found sporadically and most frequently in persons of Eastern European origin. The other three variants of Hb A2 have only been reported in a single person or in single families. Some conditions which are associated with changes in Hb A2 levels are reviewed.
本文描述了血红蛋白A2（Hb A2）的结构、特性、功能以及一些生物合成和遗传学方面的内容。对Hb A2的结构变异进行了综述，并介绍了它们的地理分布。Hb A2、Hb A2 - 弗拉特布什型和Hb A2 - 巴宾加型是黑人种群的特征，可能起源于西非或中非。Hb A2 - 斯法基亚型是加拿大美洲印第安人的特征，而Hb A2 - 印度尼西亚型是印度尼西亚/马来人群体的特征。Hb A2 - NYU型仅偶尔被发现，且最常见于东欧血统的人。Hb A2的其他三种变异仅在单一个体或单个家庭中被报道。本文还综述了一些与Hb A2水平变化相关的情况。
