Strutz J, Zöllner C, Wannenmacher M, Mann W
Univ.-HNO-Klinik Freiburg, Universität Freiburg.
Laryngol Rhinol Otol (Stuttg). 1988 Jan;67(1):38-40.
Primary cases of Hodgkin's disease in the nasopharynx are extremely rare. The authors report on two such cases: A 27 year old male had a large tumour, lined with a smooth mucous membrane, in the nasopharynx. The results of examinations of the neck, thorax, and abdomen were normal. The tumour was removed through the palate. Histological findings confirmed the diagnosis of lymphocyte-prominent Hodgkin's disease (subtype paragranuloma). 11 years ago a nasopharynx tumour was removed by adenotomy from a 57 year old female. A diffuse hyperplasia of the lymphatic tissue was diagnosed at the time. Recently cervical lymph nodes appeared, and a second tumorous lesion was discovered in the nasopharynx. Histological examination of the tumour and cervical lymph node indicated lymphocyte-prominent Hodgkin's disease (subtype paragranuloma). On re-examining histological sections from the tumour removed 11 years ago, the authors again saw the types of change indicative of Hodgkin's disease. The probable course and outcome of lymphocyte-prominent Hodgkin's disease of the nasopharynx, especially of the paragranuloma subtype of the disease, are discussed. Treatment of both patients included adjuvant extended-field radiotherapy.
原发性鼻咽癌极为罕见。作者报告了两例此类病例：一名27岁男性患者鼻咽部有一个大肿瘤，表面衬有光滑的黏膜。颈部、胸部和腹部检查结果均正常。肿瘤经腭部切除。组织学检查结果确诊为淋巴细胞为主型霍奇金病（副肉芽肿亚型）。11年前，一名57岁女性通过腺样体切除术切除了鼻咽部肿瘤。当时诊断为淋巴组织弥漫性增生。最近出现了颈部淋巴结，且在鼻咽部发现了第二个肿瘤性病变。肿瘤及颈部淋巴结的组织学检查显示为淋巴细胞为主型霍奇金病（副肉芽肿亚型）。作者在重新检查11年前切除肿瘤的组织切片时，再次发现了提示霍奇金病的病变类型。文中讨论了鼻咽部淋巴细胞为主型霍奇金病，尤其是该疾病副肉芽肿亚型的可能病程及预后。两名患者的治疗均包括辅助性扩大野放疗。
