Yamaguchi N, Brassard M, Briand R
Faculty of Pharmacy, University of Montreal, Quebec, Canada.
Life Sci. 1988;42(10):1101-8. doi: 10.1016/0024-3205(88)90566-8.
Changes in circulating plasma catecholamine (CA: E, epinephrine; NE, norepinephrine; and DA, dopamine) concentrations in aortic (AO) blood were investigated in relation to variable rates of CA secretion from both adrenal (ADR) glands in response to bilateral carotid artery occlusion (BLCO) in vagotomized dogs anesthetized with sodium pentobarbital. During BLCO (3 min), AO systolic pressure (AP) increased along with significant increases in ADR-CA output, renal venous (RV) CA output, as well as in AO-E and NE concentrations. A ratio of NE:E in ADR venous and AO blood did not exceed 0.42 +/- 0.09 and 1.09 +/- 0.24 upon BLCO, respectively. In contrast, the NE:E ratio in RV blood increased significantly from 5.39 +/- 0.91 to 9.78 +/- 1.31. Following adrenalectomy (ADRX), the increase in AO-NE in response to BLCO was significantly attenuated by approximately 56%, but the increase in RV-NE output was not affected by ADRX. The results show that in vagotomized dogs, NE is co-released with E from the adrenal glands upon BLCO. The data also indicate that the increase in AO-NE concentration was dependent to a similar extent on the simultaneous increases in ADR-NE output and neuronal NE release. We conclude that under conditions where the sympathoadrenal system is activated, circulating plasma NE concentration may be significantly affected by an increase in ADR-NE output. Sympathetic neuronal contributions would, thereby, be overestimated in assessing overall sympathetic nerve activity by measuring circulating NE. NE concentrations in local venous effluent from individual organs may be more reliable estimates of the sympathetic nerve activity.
研究了戊巴比妥钠麻醉的迷走神经切断犬双侧颈动脉闭塞（BLCO）时，主动脉（AO）血中循环血浆儿茶酚胺（CA：E，肾上腺素；NE，去甲肾上腺素；DA，多巴胺）浓度的变化与双侧肾上腺（ADR）CA分泌率变化的关系。在BLCO期间（3分钟），AO收缩压（AP）升高，同时ADR - CA输出、肾静脉（RV）CA输出以及AO - E和NE浓度显著增加。BLCO时，ADR静脉血和AO血中NE:E的比值分别不超过0.42±0.09和1.09±0.24。相反，RV血中NE:E比值从5.39±0.91显著增加到9.78±1.31。肾上腺切除（ADRX）后，BLCO引起的AO - NE增加显著减弱约56%，但RV - NE输出的增加不受ADRX影响。结果表明，在迷走神经切断犬中，BLCO时NE与E从肾上腺共同释放。数据还表明，AO - NE浓度的增加在相似程度上依赖于ADR - NE输出和神经元NE释放的同时增加。我们得出结论，在交感肾上腺系统激活的情况下，循环血浆NE浓度可能会受到ADR - NE输出增加的显著影响。因此，在通过测量循环NE评估整体交感神经活动时，交感神经元的贡献可能会被高估。来自各个器官的局部静脉流出物中的NE浓度可能是交感神经活动更可靠的估计值。
