Department of Cardiology, Faculty of Medicine, Ufuk University, Ankara, Turkey.
Coron Artery Dis. 2021 Nov 1;32(7):644-649. doi: 10.1097/MCA.0000000000001020.
The aim of this study is to evaluate the association between Nutritional Risk Index (NRI), a simple tool to assess nutritional status, and coronary artery disease severity and complexity in patients undergoing coronary angiography.
This study is a retrospective analysis of 822 patients undergoing coronary angiography. Patients with previous revascularization were excluded. Gensini and SYNTAX scores were calculated according to the angiographic images to determine atherosclerosis severity. NRI was calculated as follows: NRI = [15.19 × serum albumin (g/dl)] + [41.7 × (body weight/ideal body weight)]. In patients ≥65 years of age, Geriatric NRI (GNRI) was used instead of NRI. GNRI was calculated as follows: GNRI = [14.89 × serum albumin (g/dl)] + [41.7 × (body weight/ideal body weight)]. Patients were then divided into three groups as previously reported: NRI < 92, NRI 92-98 and NRI > 98. Gensini and SYNTAX scores were compared between three groups.
The mean age of study population was 61.9 ± 11.1 years. NRI < 92, 92-98, and >98 was measured in 212, 321 and 289 patients, respectively. There was no difference regarding to sex, BMI, smoking, hypertension and diabetes mellitus between three groups. Patients with NRI < 92 had the highest mean Gensini score than the patients with NRI 92-98 and NRI > 98 (38.0 ± 40.6 vs. 31.17 ± 42.4 vs. 25.8 ± 38.4, P = 0.005). Also patients with NRI < 92 had the highest mean SYNTAX score than the patients with NRI 92-98 and NRI > 98 (11.8 ± 12.9 vs. 9.3 ± 12.4 vs. 7.7 ± 11.8, P = 0.001). Also, Gensini score of ≥20 and high SYNTAX score of ≥33 were associated with lower NRI (P < 0.001 and P < 0.001, respectively).
In our study, nutritional status evaluated by the NRI was associated with more extensive and complex coronary atherosclerosis in patients undergoing coronary angiography.
本研究旨在评估营养风险指数（NRI）这一评估营养状况的简单工具与接受冠状动脉造影的患者的冠状动脉疾病严重程度和复杂性之间的关联。
这是一项对 822 例接受冠状动脉造影的患者进行的回顾性分析。排除了既往血运重建的患者。根据血管造影图像计算 Gensini 和 SYNTAX 评分以确定动脉粥样硬化严重程度。NRI 的计算方法如下：NRI = [15.19×血清白蛋白（g/dl）]+[41.7×（体重/理想体重）]。对于≥65 岁的患者，使用老年 NRI（GNRI）代替 NRI。GNRI 的计算方法如下：GNRI = [14.89×血清白蛋白（g/dl）]+[41.7×（体重/理想体重）]。然后，根据之前的报道将患者分为三组：NRI<92、92-98 和 NRI>98。比较三组之间的 Gensini 和 SYNTAX 评分。
研究人群的平均年龄为 61.9±11.1 岁。NRI<92、92-98 和>98 的患者分别为 212、321 和 289 例。三组间性别、BMI、吸烟、高血压和糖尿病无差异。NRI<92 的患者的平均 Gensini 评分高于 NRI 92-98 和 NRI>98 的患者（38.0±40.6 比 31.17±42.4 比 25.8±38.4，P=0.005）。NRI<92 的患者的平均 SYNTAX 评分也高于 NRI 92-98 和 NRI>98 的患者（11.8±12.9 比 9.3±12.4 比 7.7±11.8，P=0.001）。此外，Gensini 评分≥20 和 SYNTAX 评分高≥33 与较低的 NRI 相关（P<0.001 和 P<0.001）。
在本研究中，通过 NRI 评估的营养状况与接受冠状动脉造影的患者更广泛和复杂的冠状动脉粥样硬化有关。
