Department of Pathology, Anhui Medical University, Hefei, Anhui, P.R China.
Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P.R China.
J Int Med Res. 2021 Jan;49(1):300060520982804. doi: 10.1177/0300060520982804.
is a rare fungal cause of neonatal sepsis. Premature and very low birthweight infants are at especially high risk of neonatal fungal infections. There have been no reports of infection in Anhui Province, China. Here, we report a case of fungemia in a newborn boy admitted 30 minutes after delivery with grunting, cyanosis, and asphyxia. was identified as the causative organism using blood culture, DNA sequencing, and mass spectrometric analysis. After 20 days of fluconazole therapy, the patient's symptoms stabilized. Together with other relevant literature, this report provides evidence that premature neonates are at increased risk of fungal infections and that fungemia should be diagnosed early using blood cultures to enable effective treatment. Fluconazole may be effective for treating neonates with infection.
是一种罕见的真菌性新生儿败血症病因。早产儿和极低出生体重儿尤其容易发生新生儿真菌感染。在中国安徽省尚未有感染的报告。在这里,我们报告了一例在出生后 30 分钟因呻吟、发绀和窒息而入院的新生儿男孩的病例。通过血液培养、DNA 测序和质谱分析鉴定为致病病原体。经过 20 天氟康唑治疗后,患者症状稳定。结合其他相关文献,本报告表明早产儿真菌感染风险增加,应通过血液培养早期诊断真菌血症,以实现有效治疗。氟康唑可能对治疗新生儿感染有效。