Wagatsuma Kei, Miwa Kenta, Sakata Muneyuki, Ishibashi Kenji, Ishii Kenji
Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology.
School of Health Science, International University of Health and Welfare.
Nihon Hoshasen Gijutsu Gakkai Zasshi. 2021;77(1):32-40. doi: 10.6009/jjrt.2021_JSRT_77.1.32.
F-florbetapir is an amyloid β (Aβ) -targeted F-labeled positron emission tomography (PET) tracer for the clinical diagnosis of Alzheimer's disease. The standardized uptake value ratio (SUVR) serves as a tool with which to differentially diagnose. The present study aimed to cross-validate and compare SUVR derived from Amygo neuro and MIMneuro software.
We injected 40 individuals with F-florbetapir and then acquired PET images from 50 to 60 minutes later. All images were separately normalized to the standard F-florbetapir PET template using Amygo neuro and MIMneuro. Volumes of interest (VOIs) were automatically placed on six target regions each in Amygo neuro and MIMneuro. The composite SUVR (cSUVR) and regional SUVR (rSUVR) were calculated from mean values measured in VOI. A cSUVR of>1.10 was defined as representing Aβ positivity. Correlation coefficients were calculated in the two types of software.
A cSUVR>1.10 was determined by Amygo neuro and MIMneuro in 15 of the 40 individuals. The rSUVR in the posterior cingulate, parietal lobe, precuneus, and temporal lobe significantly differed between Amygo neuro and MIMneuro, whereas the cSUVR did not. The SUVR calculated by the two types of software closely correlated to each other (R=0.89-0.96, P<0.05).
The cSUVR was not different between Amygo neuro and MIMneuro. We suggest that Amygo neuro is comparable to MIMneuro in quantitative analysis using SUVR for F-florbetapir imaging, thus facilitating the use of standardized quantitative approaches to amyloid PET imaging.
F-氟代硼吡咯是一种靶向淀粉样β（Aβ）的F标记正电子发射断层扫描（PET）示踪剂，用于阿尔茨海默病的临床诊断。标准化摄取值比率（SUVR）是一种用于鉴别诊断的工具。本研究旨在对源自Amygo neuro和MIMneuro软件的SUVR进行交叉验证和比较。
我们给40名个体注射F-氟代硼吡咯，然后在50至60分钟后采集PET图像。所有图像分别使用Amygo neuro和MIMneuro归一化到标准F-氟代硼吡咯PET模板。在Amygo neuro和MIMneuro中，感兴趣区（VOI）自动放置在六个目标区域上。根据在VOI中测量的平均值计算复合SUVR（cSUVR）和区域SUVR（rSUVR）。cSUVR>1.10被定义为代表Aβ阳性。计算两种软件中的相关系数。
在40名个体中，Amygo neuro和MIMneuro确定15名个体的cSUVR>1.10。Amygo neuro和MIMneuro之间，后扣带回、顶叶、楔前叶和颞叶的rSUVR有显著差异，而cSUVR没有。两种软件计算的SUVR彼此密切相关（R = 0.89 - 0.96，P<0.05）。
Amygo neuro和MIMneuro之间的cSUVR没有差异。我们认为在使用SUVR对F-氟代硼吡咯成像进行定量分析时，Amygo neuro与MIMneuro相当，从而便于使用标准化定量方法进行淀粉样PET成像。
